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Ponalrestat

CAS No. 72702-95-5

Ponalrestat( ICI 128436 | MK-538 | Ponalrestat )

Catalog No. M15783 CAS No. 72702-95-5

ponalrestat, an aldose reductase inhibitor, activates lipoprotein lipase (LPL) activity in the adipose tissue and alleviates the cachectic symptoms induced by B16 melanoma in mice

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Ponalrestat
  • Note
    Research use only, not for human use.
  • Brief Description
    ponalrestat, an aldose reductase inhibitor, activates lipoprotein lipase (LPL) activity in the adipose tissue and alleviates the cachectic symptoms induced by B16 melanoma in mice
  • Description
    ponalrestat, an aldose reductase inhibitor, activates lipoprotein lipase (LPL) activity in the adipose tissue and alleviates the cachectic symptoms induced by B16 melanoma in mice.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Adult female Sprague-Dawley ratsDosage:10, 50 mg/kg Administration:Orally; daily; 8 weeks Result:Reduced sorbitol accumulation.
  • Synonyms
    ICI 128436 | MK-538 | Ponalrestat
  • Pathway
    Endocrinology/Hormones
  • Target
    Reductase
  • Recptor
    Aldose reductase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    72702-95-5
  • Formula Weight
    391.19
  • Molecular Formula
    C17H12BrFN2O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 10 mM
  • SMILES
    O=C(O)CC1=NN(CC2=CC=C(Br)C=C2F)C(C3=C1C=CC=C3)=O
  • Chemical Name
    2-(3-(4-bromo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Pekiner C, McLean WG. Br J Pharmacol. 1990 Dec;101(4):978-80.
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