Zopolrestat

Research use only, not for human use.

Zopolrestat is a potent inhibitor of aldose reductase (IC50 = 3.1 nM).

Zopolrestat is a potent inhibitor of aldose reductase (IC50 = 3.1 nM).(In Vitro):Zopolrestat is a potent inhibitor of the enzymatic reduction of glyceraldehyde and glucose.(In Vivo):After the administration of Zopolrestat (2.5 mg/kg-50 mg/kg; p.o), the ED50s in reversing already elevated sorbitol accumulation in rat sciatic nerve, retina, and lens in a chronic test were 1.9, 17.6, and 18.4 mg/kg, respectively.

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Animal Model:Male Sprague-Dawley rats (made diabetic by iv injection of streptozotocin). Dosage:2.5 mg/kg-50 mg/kg Administration:P.o.; once-a-day for 5 days Result:Its ED50s in reversing already elevated sorbitol accumulation in rat sciatic nerve, retina, and lens in a chronic test were 1.9, 17.6, and 18.4 mg/kg, respectively.

CP 73850 | CP73850 | CP-73850 | Zopolrestat | Zopolrestatum

Endocrinology/Hormones

Reductase

gastrin

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110703-94-1

419.38

C19H12F3N3O3S

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (238.45 mM)

OC(=O)Cc1nn(Cc2nc3cc(ccc3s2)C(F)(F)F)c(=O)c2ccccc12

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(-20℃)

With Ice Pack

≥ 2 years