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Lidorestat
CAS No. 245116-90-9
Lidorestat( —— )
Catalog No. M33408 CAS No. 245116-90-9
Lidorestat (IDD-676) is an aldose reductase inhibitor (IC50: 5 nM) with effective, selective and oral activity. Lidorestat improves nerve conduction and reduces the formation of cataracts.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 43 | In Stock |
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| 5MG | 38 | In Stock |
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| 10MG | 61 | In Stock |
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| 25MG | 103 | In Stock |
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| 50MG | 153 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameLidorestat
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NoteResearch use only, not for human use.
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Brief DescriptionLidorestat (IDD-676) is an aldose reductase inhibitor (IC50: 5 nM) with effective, selective and oral activity. Lidorestat improves nerve conduction and reduces the formation of cataracts.
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DescriptionLidorestat (IDD-676) is a potent, selective and orally active aldose reductase inhibitor with an IC50 of 5 nM. Lidorestat can be used for chronic diabetes complications. Lidorestat also improves nerve conduction and reduces cataract formation.
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In VitroFrom in vitro experiments, Lidorestat has a reported IC50 against recombinant human aldose reductase (/h/-ALR2) of 5 μM. Against recombinant human aldehyde reductase (/h/-ALR1), Lidorestat has a reported IC50 of 27,000 μM, yielding a selectivity of /h/-ALR1//h/-ALR2 of 5400:1.
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In VivoLidorestat (25 mg/kg/day; oral administration; twice daily; for 6 weeks; diabetic mice) treatment decreases fructose and reduces mortality in diabetic hAR-expressing mice. And Lidorestat does not affect weight.Animal Model:Diabeticlow-density lipoprotein (LDL) receptor-deficient [Ldlr(-/-)] mice Dosage:25 mg/kg/day Administration:Oral administration; twice daily; for 6 weeks Result: Diabetic hAR-expressing mice had decreased fructose and reduced mortality.
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetReductase
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RecptorReductase
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Research Area——
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Indication——
Chemical Information
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CAS Number245116-90-9
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Formula Weight376.35
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Molecular FormulaC18H11F3N2O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (132.86 mM; Ultrasonic (<60°C)
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SMILESOC(=O)Cn1cc(Cc2nc3c(F)c(F)cc(F)c3s2)c2ccccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Noh HL, et al. Regulation of plasma fructose and mortality in mice by the aldose reductase inhibitor lidorestat. J Pharmacol Exp Ther. 2009 Feb;328(2):496-503.?
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