NBQX Disodium

Research use only, not for human use.

NBQX Disodium (FG9202 disodium) is a highly selective, competitive AMPA receptor antagonist with neuroprotective and anticonvulsant activity.

NBQX disodium (FG9202 disodium) is a highly selective and competitive AMPA receptor antagonist. NBQX disodium has neuroprotective and anticonvulsant activity.

NBQX disodium (FG9202 disodium) has a high affinity for AMPA and kainate binding sites with little or no affinity for the glutamate recognition site on the NMDA receptor complex.

NBQX disodium (FG9202; 20 mg/kg, i.p.; for 3 days) decreases seizures induced by PTZ. NBQX disodium is neuroprotective in a focal ischaemia model in the rat when given as an i.v. bolus dose of 30 mg/kg at the time of MCA occlusion and again at 1 h post occlusion. Animal Model:Male Wistar rats that weighed 220-240 g with pentylenetetrazole (PTZ)Dosage:20 mg/kg Administration:IP; for 3 days Result:Effectively reversed the behavioral abnormality of epileptic seizures of chronic PTZ administration (50mg/kg; i.p.; for 28 days) in rats.

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Neuroscience

GluR

GluR

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479347-86-9

380.24

C12H6N4Na2O6S

>98% (HPLC)

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NS(=O)(C1=CC=CC2=C1C([N+]([O-])=O)=CC3=C2[N-]C(C([N-]3)=O)=O)=O.[Na+].[Na+]

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(-20℃)

With Ice Pack

≥ 2 years