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Home - Products - Neuroscience - P2 Receptor - JNJ-47965567

JNJ-47965567

CAS No. 1428327-31-4

JNJ-47965567( JNJ-479655 )

Catalog No. M23587 CAS No. 1428327-31-4

JNJ-47965567 is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel(with pKis of 7.9 and 8.7 for human and rat P2X7, respectively).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 79 In Stock
2MG 43 In Stock
5MG 72 In Stock
10MG 117 In Stock
25MG 238 In Stock
50MG 346 In Stock
100MG 483 In Stock
200MG 691 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    JNJ-47965567
  • Note
    Research use only, not for human use.
  • Brief Description
    JNJ-47965567 is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel(with pKis of 7.9 and 8.7 for human and rat P2X7, respectively).
  • Description
    JNJ-47965567 is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel(with pKis of 7.9 and 8.7 for human and rat P2X7, respectively).
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male Sprague Dawley rats Dosage:30 mg/kg, 100 mg/kg Administration:Subcutaneous injection; 30 minutes prior to Bz-ATP infusion Result:Significantly attenuated IL-1β release at 100 mg/kg, with no effect at 30 mg/kg dose group.
  • Synonyms
    JNJ-479655
  • Pathway
    Neuroscience
  • Target
    P2 Receptor
  • Recptor
    human P2X7|P2X7
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1428327-31-4
  • Formula Weight
    488.64
  • Molecular Formula
    C28H32N4O2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:200 mg/mL (409.30 mM; Need ultrasonic)
  • SMILES
    O=C(C1=CC=CN=C1SC2=CC=CC=C2)NCC3(N4CCN(C5=CC=CC=C5)CC4)CCOCC3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567.[J]. British Journal of Pharmacology, 2013, 170(3):624-640.
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