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JNJ-47965567
CAS No. 1428327-31-4
JNJ-47965567( JNJ-479655 )
Catalog No. M23587 CAS No. 1428327-31-4
JNJ-47965567 is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel(with pKis of 7.9 and 8.7 for human and rat P2X7, respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 79 | In Stock |
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| 2MG | 43 | In Stock |
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| 5MG | 72 | In Stock |
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| 10MG | 117 | In Stock |
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| 25MG | 238 | In Stock |
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| 50MG | 346 | In Stock |
|
| 100MG | 483 | In Stock |
|
| 200MG | 691 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameJNJ-47965567
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NoteResearch use only, not for human use.
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Brief DescriptionJNJ-47965567 is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel(with pKis of 7.9 and 8.7 for human and rat P2X7, respectively).
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DescriptionJNJ-47965567 is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel(with pKis of 7.9 and 8.7 for human and rat P2X7, respectively).
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In Vitro——
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In VivoAnimal Model:Male Sprague Dawley rats Dosage:30 mg/kg, 100 mg/kg Administration:Subcutaneous injection; 30 minutes prior to Bz-ATP infusion Result:Significantly attenuated IL-1β release at 100 mg/kg, with no effect at 30 mg/kg dose group.
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SynonymsJNJ-479655
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PathwayNeuroscience
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TargetP2 Receptor
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Recptorhuman P2X7|P2X7
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Research Area——
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Indication——
Chemical Information
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CAS Number1428327-31-4
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Formula Weight488.64
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Molecular FormulaC28H32N4O2S
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Purity>98% (HPLC)
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SolubilityDMSO:200 mg/mL (409.30 mM; Need ultrasonic)
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SMILESO=C(C1=CC=CN=C1SC2=CC=CC=C2)NCC3(N4CCN(C5=CC=CC=C5)CC4)CCOCC3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567.[J]. British Journal of Pharmacology, 2013, 170(3):624-640.
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