Cart
sales@molnova.com
Home - Products - Neuroscience - P2 Receptor - RO3

RO3

CAS No. 1026582-88-6

RO3( —— )

Catalog No. M22083 CAS No. 1026582-88-6

RO3 is a selective antagonist of homomeric P2X3 and heteromeric P2X2/3 receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 120 In Stock
5MG 107 In Stock
10MG 176 In Stock
25MG 345 In Stock
50MG 538 In Stock
100MG 768 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    RO3
  • Note
    Research use only, not for human use.
  • Brief Description
    RO3 is a selective antagonist of homomeric P2X3 and heteromeric P2X2/3 receptor.
  • Description
    RO3 is a selective antagonist of homomeric P2X3 and heteromeric P2X2/3 receptor.
  • In Vitro
    ——
  • In Vivo
    In a guinea pig ureter-afferent nerve preparation, and mouse bladder-pelvic nerve preparation, RO-3 dose-dependently reduces afferent nerve activity induced by distension or α,β-meATP.RO-3 has activity in several rodent models of pain, as well as in cystometry models optimized to measure various parameters associated with sensory regulation of the micturition reflex.RO-3 has moderate to high metabolic stability in rat and human hepatocytes and liver microsomes, and is highly permeable, orally bioavailable (14%), and has a reasonable in vivo plasma half-life (t1/2=0.41?h) in rats.
  • Synonyms
    ——
  • Pathway
    Neuroscience
  • Target
    P2 Receptor
  • Recptor
    P2X3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1026582-88-6
  • Formula Weight
    302.38
  • Molecular Formula
    C16H22N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (413.40 mM)
  • SMILES
    COc1cc(Cc2cnc(N)nc2N)c(cc1OC)C(C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Gever J R , Cockayne D A , Dillon M P , et al. Pharmacology of P2X channels[J]. Pflügers Archiv European Journal of Physiology, 2006, 452(5):513-37.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • APY29

    APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.

  • JNJ-47965567

    JNJ-47965567 is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel(with pKis of 7.9 and 8.7 for human and rat P2X7, respectively).

  • Prasugrel

    Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine.

Sign In Join Free