1-Ethynylnaphthalene( —— )

Catalog No. M20721 CAS No. 15727-65-8

1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 IB1.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	28	In Stock
100MG	Get Quote	In Stock
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1G	33	In Stock

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Biological Information

Product Name

1-Ethynylnaphthalene
Note

Research use only, not for human use.
Brief Description

1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 IB1.
Description

1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 IB1.
In Vitro

1-Ethynylnaphthalene, selective inhibitor of cytochrome P450 IB1, does not affect 2-hydroxylation but inhibits 4-hydroxylation by 38%. At higher concentrations, 1-Ethynylnaphthalene inhibits 2-hydroxylation of 2-Hydroxylation of estradiol (E2) by ~30% and 4-hydroxylation of E2 by up to 80%.
In Vivo

——
Synonyms

——
Pathway

Metabolic Enzyme/Protease
Target

P450
Recptor

CYP450 1B1
Research Area

——
Indication

——

Chemical Information

CAS Number

15727-65-8
Formula Weight

152.19
Molecular Formula

C12H8
Purity

>98% (HPLC)
Solubility

DMSO:125 mg/mL (821.34 mM)
SMILES

C#Cc1cccc2ccccc12
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Hammons G J Alworth W L Hopkins N E et al. 2-Ethynylnaphthalene as a mechanism-based inactivator of the cytochrome P-450 catalyzed N-oxidation of 2-naphthylamine[J]. Chemical Research in Toxicology 1989 2(6):367-374.

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