OSI-420( OSI420 | CP 473420 | Desmethyl Erlotinib )

Catalog No. M17392 CAS No. 183320-51-6

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Product Name

OSI-420
Note

Research use only, not for human use.
Brief Description

OSI-420 (Desmethyl Erlotinib, CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for human EGFR and EGFR autophosphorylation in tumor cells.
Description

OSI-420 (CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells.
In Vitro

——
In Vivo

Desmethyl Erlotinib exhibits t1/2 of 11.96±2.01 h in a pharmacokinetic study in Wistar rats.
Synonyms

OSI420 | CP 473420 | Desmethyl Erlotinib
Pathway

Neuroscience
Target

GluR
Recptor

EGFR
Research Area

Cancer
Indication

——

CAS Number

183320-51-6
Formula Weight

415.87
Molecular Formula

C21H21N3O4·HCl
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 4.2 mg/mL; 10.10 mM
SMILES

Cl.COCCOC1=CC2=C(C=C1OCCO)C(NC1=CC=CC(=C1)C#C)=NC=N2
Chemical Name

2-[[4-[(3-Ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl]oxy]ethanol

1. Svedberg A,et al. J Pharm Biomed Anal. 2015 Mar 25;107:186-95.

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