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OSI-420
CAS No. 183320-51-6
OSI-420( OSI420 | CP 473420 | Desmethyl Erlotinib )
Catalog No. M17392 CAS No. 183320-51-6
OSI-420 (Desmethyl Erlotinib, CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for human EGFR and EGFR autophosphorylation in tumor cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 123 | In Stock |
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| 2MG | 72 | In Stock |
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| 5MG | 111 | In Stock |
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| 10MG | 188 | In Stock |
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| 25MG | 335 | In Stock |
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| 50MG | 495 | In Stock |
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| 100MG | 705 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameOSI-420
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NoteResearch use only, not for human use.
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Brief DescriptionOSI-420 (Desmethyl Erlotinib, CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for human EGFR and EGFR autophosphorylation in tumor cells.
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DescriptionOSI-420 (CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells.
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In Vitro——
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In VivoDesmethyl Erlotinib exhibits t1/2 of 11.96±2.01 h in a pharmacokinetic study in Wistar rats.
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SynonymsOSI420 | CP 473420 | Desmethyl Erlotinib
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PathwayNeuroscience
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TargetGluR
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RecptorEGFR
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number183320-51-6
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Formula Weight415.87
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Molecular FormulaC21H21N3O4·HCl
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 4.2 mg/mL; 10.10 mM
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SMILESCl.COCCOC1=CC2=C(C=C1OCCO)C(NC1=CC=CC(=C1)C#C)=NC=N2
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Chemical Name2-[[4-[(3-Ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl]oxy]ethanol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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FPTQ B
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S-(4-Hydroxybenzyl)g...
L-γ-Glutamyl-S-[(4-hydroxyphenyl)methyl] was isolated as the major principle responsible for the inhibition of the in vitro binding of kainic acid to brain glutamate receptors by water extracts of the plant Gastrodia elata.
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(S)-MCPG
(S)-MCPG ((+)-MCPG) is a class I/II metabotropic glutamate receptors (mGluRs) antagonist that blocks spatial learning and long-term enhancement of the dentate gyrus in vivo in rats, and can be used to study neurological disorders.
