LRE1 (b)( LRE 1 | LRE-1 | RU-0204277 | RU 0204277 )

Catalog No. M11791 CAS No. 1424605-11-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

LRE1 (b)
Note

Research use only, not for human use.
Brief Description

A novel potent, specific and allosteric soluble adenylyl cyclase (sAC) inhibitor with IC50 of 3.3 uM in RF-MSS assays.
Description

A novel potent, specific and allosteric soluble adenylyl cyclase (sAC) inhibitor with IC50 of 3.3 uM in RF-MSS assays; does not inhibit other transmembrane adenylyl cyclases (tmACs) indluding tmACs I, II, V, VIII and IX at 50 uM; binds to the bicarbonate activator binding site and inhibited sAC via a unique allosteric mechanism; inhibits cAMP accumulation in 4-4 cells with an IC50 of 11 uM, and is non-toxic and does not uncouple mitochondria.
In Vitro

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In Vivo

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Synonyms

LRE 1 | LRE-1 | RU-0204277 | RU 0204277
Pathway

Metabolic Enzyme/Protease
Target

Adenylate Cyclase
Recptor

Adenylate Cyclase
Research Area

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Indication

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CAS Number

1424605-11-7
Formula Weight

280.774
Molecular Formula

C12H13ClN4S
Purity

>98% (HPLC)
Solubility

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SMILES

C1CC1N(CC2=CSC=C2)C3=CC(=NC(=N3)N)Cl
Chemical Name

6-chloro-N4-cyclopropyl-N4-[(thiophen-3-yl)methyl]pyrimidine-2,4-diamine

1. Ramos-Espiritu L, et al. Nat Chem Biol. 2016 Oct;12(10):838-44.

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