NKH 477 hydrochloride( Colforsin dapropate )

Catalog No. M11605 CAS No. 138605-00-2

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Product Name

NKH 477 hydrochloride
Note

Research use only, not for human use.
Brief Description

NKH 477 hydrochloride (Colforsin dapropate) is a water-soluble analog of Forskolin and a potent activator of adenylyl cyclase.
Description

NKH 477 hydrochloride (Colforsin dapropate) is a water-soluble analog of Forskolin and a potent activator of adenylyl cyclase, shows some selectivity for cardiac (type V) adenylyl cyclase; increases cAMP accumulation in HEK293 cells stably overexpressing type V more than forskolin; A PKA activator.Heart Failure Approveed.
In Vitro

——
In Vivo

NKH477 (Colforsin dapropate hydrochloride) (orally; 1-3 mg/kg/day; days 3 and 5) prolonged lung allograft survival in a dose dependent manner. Animal Model:Specific-pathogen-free inbred male Lewis rats (LEW) weighing 250 to 280 g Dosage:1, 2 or 3 mg/kg/day Administration:Orally; daily; Days 3 and 5 Result:Prolonged lung allograft survival in a dose dependent manner.
Synonyms

Colforsin dapropate
Pathway

Metabolic Enzyme/Protease
Target

Adenylate Cyclase
Recptor

Adenylate Cyclase
Research Area

——
Indication

——

CAS Number

138605-00-2
Formula Weight

546.1
Molecular Formula

C27H43NO8.HCl
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (228.90 mM)
SMILES

CC(C)CCC(O[C@@H]([C@@]1([H])C(C)(C)CC[C@H](O)[C@@]12C)[C@H](OC(C)=O)[C@]3(C)[C@]2(O)C(C[C@](C)(C=C)O3)=O)=O.[H]Cl
Chemical Name

(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-β-alanine, N,N-dimethyl-oxo-1H-naphtho[2,1-b]pyran-6-yl ester hydrochloride

1. Hosono M, et al. J Cardiovasc Pharmacol. 1992 Apr;19(4):625-34. 2. Toya Y, et al. J Mol Cell Cardiol. 1998 Jan;30(1):97-108.

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