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VTP-27999 2,2,2-trifluoroacetate
CAS No. 1013937-63-7
VTP-27999 2,2,2-trifluoroacetate( VTP 27999, 2,2,2-trifluoroacetate | VTP27999 )
Catalog No. M10079 CAS No. 1013937-63-7
A potent, highly selective renin inhibitor with IC50 of 0.47 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 88 | Get Quote |
|
| 10MG | 147 | Get Quote |
|
| 25MG | 267 | Get Quote |
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| 50MG | 475 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameVTP-27999 2,2,2-trifluoroacetate
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, highly selective renin inhibitor with IC50 of 0.47 nM.
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DescriptionA potent, highly selective renin inhibitor with IC50 of 0.47 nM; displays >1000-fold selectivity for renin over a panel of >150 receptors, ion channels, and enzymes, and has an IC50 value >30 uM against CYP3A4; demonstrates >15% oral bioavailability in three species, oral efficacy in a double transgenic rat model of hypertension, and good exposure in humans.Hypertension Phase 1 Clinical.
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In Vitro——
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In Vivo——
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SynonymsVTP 27999, 2,2,2-trifluoroacetate | VTP27999
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PathwayMetabolic Enzyme/Protease
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TargetRenin
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RecptorRenin
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Research AreaCardiovascular Disease
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IndicationHypertension
Chemical Information
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CAS Number1013937-63-7
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Formula Weight639.1039
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Molecular FormulaC28H42ClF3N4O7
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(OC)NCCO[C@@H](C1=CC=CC(Cl)=C1)[C@H]2CN(C(NC[C@@H](NC)C[C@@H]3COCCC3)=O)CCC2.O=C(O)C(F)(F)F
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Chemical NameCarbamic acid, N-[2-[(R)-(3-chlorophenyl)[(3R)-1-[[[(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl]amino]carbonyl]-3-piperidinyl]methoxy]ethyl]-, methyl ester, 2,2,2-trifluoroacetate (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jia L, et al. ACS Med Chem Lett. 2011 Aug 9;2(10):747-51.
2. Krop M, et al. Hypertension. 2013 May;61(5):1075-82.
3. Balcarek J, et al. Hypertension. 2014 May;63(5):942-50.
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