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VTP-27999 hydrochloride
CAS No. 1264191-73-2
VTP-27999 hydrochloride( —— )
Catalog No. M11106 CAS No. 1264191-73-2
A potent, highly selective renin inhibitor with IC50 of 0.47 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 1224 | Get Quote |
|
| 100MG | 1971 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameVTP-27999 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, highly selective renin inhibitor with IC50 of 0.47 nM.
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DescriptionA potent, highly selective renin inhibitor with IC50 of 0.47 nM; displays >1000-fold selectivity for renin over a panel of >150 receptors, ion channels, and enzymes, and has an IC50 value >30 uM against CYP3A4; demonstrates >15% oral bioavailability in three species, oral efficacy in a double transgenic rat model of hypertension, and good exposure in humans.Hypertension Phase 1 Clinical.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetRenin
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RecptorRenin
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Research AreaCardiovascular Disease
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IndicationHypertension
Chemical Information
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CAS Number1264191-73-2
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Formula Weight561.5415
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Molecular FormulaC26H42Cl2N4O5
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Purity>98% (HPLC)
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SolubilityH2O: ≥ 100 mg/mL
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SMILESCNC(CC1CCCOC1)CNC(=O)N2CCCC(C2)C(C3=CC(=CC=C3)Cl)OCCNC(=O)OC.Cl
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Chemical NameCarbamic acid, N-[2-[(R)-(3-chlorophenyl)[(3R)-1-[[[(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl]amino]carbonyl]-3-piperidinyl]methoxy]ethyl]-, methyl ester, hydrochloride (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jia L, et al. ACS Med Chem Lett. 2011 Aug 9;2(10):747-51.
2. Krop M, et al. Hypertension. 2013 May;61(5):1075-82.
3. Balcarek J, et al. Hypertension. 2014 May;63(5):942-50.
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