Imarikiren hydrochloride( TAK-272 | TAK 272 hydrochloride | TAK272 )

Catalog No. M10731 CAS No. 1202269-24-6

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Product Name

Imarikiren hydrochloride
Note

Research use only, not for human use.
Brief Description

A highly potent, selective, orally active renin inhibitor with IC50 of 2.1 nM in hPRA assay.
Description

A highly potent, selective, orally active renin inhibitor with IC50 of 2.1 nM in hPRA assay; displays excellent selectivity against other aspartic proteases, such as pepsin and cathepsin D (IC50>10 uM); exhibits a dramatically improved PK profile in rats, and long-lasting antihypertensive efficacy in vivo.Diabetes Phase 2 Clinical.
In Vitro

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In Vivo

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Synonyms

TAK-272 | TAK 272 hydrochloride | TAK272
Pathway

Metabolic Enzyme/Protease
Target

Renin
Recptor

Renin
Research Area

Metabolic Disease
Indication

Diabetes

CAS Number

1202269-24-6
Formula Weight

536.114
Molecular Formula

C27H42ClN5O4
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

CC(C)CN(C1CC(CNC1)C(=O)N2CCOCC2)C(=O)C3=NC4=CC=CC=C4N3CCCCOC.Cl
Chemical Name

1-(4-methoxybutyl)-N-(2-methylpropyl)-N-[(3S,5R)-5-(morpholin-4-yl)carbonylpiperidin-3-yl]-1H-benzimidazole-2-carboxamide hydrochloride

1. Imaeda Y, et al. ACS Med Chem Lett. 2016 Sep 12;7(10):933-938.

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