MK-8141( ACT-077825 )

Catalog No. M16496 CAS No. 903579-36-2

MK-8141 (ACT-077825) is a novel potent, selective, direct Renin inhibitor for the treatment of cardiovascular disorders.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

MK-8141
Note

Research use only, not for human use.
Brief Description

MK-8141 (ACT-077825) is a novel potent, selective, direct Renin inhibitor for the treatment of cardiovascular disorders.
Description

MK-8141 (ACT-077825) is a novel potent, selective, direct Renin inhibitor for the treatment of cardiovascular disorders.Hypertension Phase 2 Discontinued.
In Vitro

——
In Vivo

——
Synonyms

ACT-077825
Pathway

Metabolic Enzyme/Protease
Target

Renin
Recptor

Renin
Research Area

Cardiovascular Disease
Indication

Hypertension

Chemical Information

CAS Number

903579-36-2
Formula Weight

620.615
Molecular Formula

C35H39Cl2N3O3
Purity

>98% (HPLC)
Solubility

——
SMILES

CC1=C(C(=CC=C1)CN2CC3CC(=C(C(C2)N3C4CC4)C(=O)N)C5=CC=C(C=C5)OCCOC6=C(C=C(C=C6Cl)C)Cl)C
Chemical Name

(1S,5R)-N-cyclopropyl-7-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)phenyl)-N-(2,3-dimethylbenzyl)-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxamide

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Dingemanse J, et al. Pharmacology. 2014;94(3-4):135-42. doi: 10.1159/000362822. 2. Nicolas LB, et al. J Cardiovasc Pharmacol. 2013 Jan;61(1):42-50. 3. Jones-Burton C, et al. J Am Soc Hypertens. 2010 Sep-Oct;4(5):219-26.

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