ZGN-1061( Aclimostat | ZGN1061 )

Catalog No. M13245 CAS No. 2082752-83-6

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HNMR

HPLC

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Product Name

ZGN-1061
Note

Research use only, not for human use.
Brief Description

ZGN-1061 (Aclimostat) is a novel potent, selective Methionine aminopeptidase 2 (MetAP2) inhibitor being investigated for treatment of diabetes and obesity.
Description

ZGN-1061 (Aclimostat) is a novel potent, selective Methionine aminopeptidase 2 (MetAP2) inhibitor being investigated for treatment of diabetes and obesity; reduces body weight in diet-induced obese (DIO) insulin-resistant mice, also produced improvements in metabolic parameters, including plasma glucose and insulin, and, in HepG2 cells, initiated gene changes similar to beloranib; does not increase coagulation markers in dogs and ZGN-1061 had a greatly improved safety profile in rats relative to beloranib.Diabetes Phase 2 Clinical.
In Vitro

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In Vivo

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Synonyms

Aclimostat | ZGN1061
Pathway

Metabolic Enzyme/Protease
Target

Aminopeptidase
Recptor

Aminopeptidase
Research Area

Metabolic Disease
Indication

Diabetes

CAS Number

2082752-83-6
Formula Weight

478.63
Molecular Formula

C26H42N2O6
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 230 mg/mL (480.55 mM)
SMILES

O=C(N1CC(CCN2CCOCC2)C1)O[C@H](CC3)[C@@H](OC)[C@H]([C@@]4(C)O[C@@H]4C/C=C(C)\C)[C@]53CO5
Chemical Name

(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3- methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl 3-[2-(morpholin-4-yl)ethyl]azetidine-1-carboxylate

1. Burkey BF, et al. J Pharmacol Exp Ther. 2018 Feb 28. pii: jpet.117.246272.

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