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A-357300
CAS No. 369358-07-6
A-357300( A357300 )
Catalog No. M14270 CAS No. 369358-07-6
A-357300 is a potent, selective, reversible MetAP2 inhibitor with IC50 of 0.12 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1143 | Get Quote |
|
| 50MG | 2322 | Get Quote |
|
| 100MG | 3060 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameA-357300
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NoteResearch use only, not for human use.
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Brief DescriptionA-357300 is a potent, selective, reversible MetAP2 inhibitor with IC50 of 0.12 uM.
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DescriptionA-357300 is a potent, selective, reversible MetAP2 inhibitor with IC50 of 0.12 uM, does not inhibit MetAP1 or leucine aminopeptidases at 10 uM; suppresses tumor growth preclinically without the toxicities observed with TNP-470, induces cytostasis by cell cycle arrest at the G(1) phase selectively in endothelial cells and in a subset of tumor cells, but not in most primary cells of nonendothelial type; inhibits angiogenesis both in vitro and in vivo and shows potent antitumor efficacy in carcinoma, sarcoma, and neuroblastoma murine models.
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In Vitro——
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In Vivo——
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SynonymsA357300
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PathwayMetabolic Enzyme/Protease
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TargetAminopeptidase
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RecptorAminopeptidase
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Research Area——
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Indication——
Chemical Information
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CAS Number369358-07-6
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Formula Weight359.869
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Molecular FormulaC15H22ClN3O3S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NNC([C@@H](O)[C@H](N)CCSC(C)C)=O)C1=CC=CC(Cl)=C1
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Chemical NameN'-((2S,3R)-3-amino-2-hydroxy-5-(isopropylthio)pentanoyl)-3-chlorobenzohydrazide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wang J, et al. Cancer Res. 2003 Nov 15;63(22):7861-9.
2. Sheppard GS, et al. Bioorg Med Chem Lett. 2004 Feb 23;14(4):865-8.
3. Morowitz MJ, et al. Clin Cancer Res. 2005 Apr 1;11(7):2680-5.
molnova catalog
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