A-800141( A800141 )

Catalog No. M15599 CAS No. 681245-85-2

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HNMR

HPLC

MSDS

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Product Name

A-800141
Note

Research use only, not for human use.
Brief Description

A-800141 is a potent, highly specific, orally bioavailable MetAP2 inhibitor with IC50 of 12 nM.
Description

A-800141 is a potent, highly specific, orally bioavailable MetAP2 inhibitor with IC50 of 12 nM, shows no inhibition for MetAP1 (IC50>30 uM); also shows a greater selectivity against other aminopeptidases, as well as a CEREP panel of >80 receptors; causes the formation of GAPDH variants with an unprocessed N-terminal methionine in cell cultures in vitro, exhibits an antiangiogenesis effect and a broad anticancer activity in a variety of tumor xenografts including B cell lymphoma, neuroblastoma, and prostate and colon carcinomas, either as a single agent or in combination with cytotoxic agents; blocks tumor growth and MetAP2 activity in mouse models, which are causally connected to MetAP2 inhibition in vivo.
In Vitro

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In Vivo

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Synonyms

A800141
Pathway

Metabolic Enzyme/Protease
Target

Aminopeptidase
Recptor

Aminopeptidase
Research Area

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Indication

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CAS Number

681245-85-2
Formula Weight

442.574
Molecular Formula

C24H30N2O4S
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

(Z)-2-((2-(3-(diethylamino)prop-1-en-1-yl)phenyl)sulfonamido)-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid

1. Wang J, et al. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1838-43.

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