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TCN213
CAS No. 556803-08-8
TCN213( —— )
Catalog No. M21967 CAS No. 556803-08-8
TCN213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2BTCN 213 antagonism of GluN1/GluN2A NMDA receptors was dependent on glycine but independent of glutamate concentrations in external recording solutions.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameTCN213
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NoteResearch use only, not for human use.
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Brief DescriptionTCN213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2BTCN 213 antagonism of GluN1/GluN2A NMDA receptors was dependent on glycine but independent of glutamate concentrations in external recording solutions.
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DescriptionTCN213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2BTCN 213 antagonism of GluN1/GluN2A NMDA receptors was dependent on glycine but independent of glutamate concentrations in external recording solutions.?Antagonism by TCN 213 was surmountable and gave a Schild plot with unity slope.?TCN 213 block of GluN1/GluN2B NMDA receptor-mediated currents was negligible.?In cortical neurones, at a early developmental stage predominantly expressing GluN2B-containing NMDA receptors, TCN 213 failed to antagonize NMDA receptor-mediated currents or to prevent GluN2B-dependent, NMDA-induced excitoxicity.?In older cultures (DIV 14) or in neurones transfected with GluN2A subunits, TCN 213 antagonized NMDA-evoked currents.?Block by TCN 213 of NMDA currents inversely correlated with block by ifenprodil, a selective GluN2B antagonist.
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In VitroTCN 213 (30 μM) antagonizes NMDA-evoked currents in neurones transfected with GluN2A subunits.
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In Vivo——
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetNMDAR
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RecptorNMDA receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number556803-08-8
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Formula Weight376.54
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Molecular FormulaC18H24N4OS2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (663.94 mM)
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SMILESO=C(CSc1nnc(NCc2ccccc2)s1)NCC1CCCCC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Mckay S , Griffiths N H , Butters P A , et al. Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist[J]. British Journal of Pharmacology, 2012, 166(3):924-937.
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