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Home - Products - Membrane Transporter/Ion Channel - NMDAR - GNE-8324

GNE-8324

CAS No. 1698901-76-6

GNE-8324( —— )

Catalog No. M34611 CAS No. 1698901-76-6

GNE-8324 is a GluN2A selective positive allosteric modulator that selectively enhances NMDAR-mediated synaptic responses in inhibitory, but not excitatory, neurons.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GNE-8324
  • Note
    Research use only, not for human use.
  • Brief Description
    GNE-8324 is a GluN2A selective positive allosteric modulator that selectively enhances NMDAR-mediated synaptic responses in inhibitory, but not excitatory, neurons.
  • Description
    GNE-8324 is a selective GluN2A positive allosteric modulator. GNE-8324 selectively enhances NMDA receptor (NMDAR)-mediated synaptic responses in inhibitory but not excitatory neurons.
  • In Vitro
    A reciprocal allosteric interaction between the GNE-8324 and glutamate binding sites at GluN2A NMDARs such that binding of glutamate enhances binding of GNE-8324 and vice versa. GNE-8324 selectively potentiates GluN2A subunit-containing NMDARs. As a consequence, GNE-8324 potentiation is highly dependent on glutamate site occupancy with enhanced GNE-8324 binding to glutamate-bound NMDARs compared to glutamate-free NMDARs.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    NMDAR
  • Recptor
    NMDAR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1698901-76-6
  • Formula Weight
    343.42
  • Molecular Formula
    C18H18FN3OS
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1C=C(N=C2SC3=C(N12)CCC3)CN(C4=CC=C(F)C=C4)CC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lulu Yao, et al. Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity. Nat Commun. 2018 Oct 1;9(1):4000.?
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