Phellamurin

Research use only, not for human use.

Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensure the efficacy of cyclosporin, we suggest that the coadministration of Phellamurin or Phellodendron wilsonii with cyclosporin should be avoided.

Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensure the efficacy of cyclosporin, we suggest that the coadministration of Phellamurin or Phellodendron wilsonii with cyclosporin should be avoided.(In Vitro):Administration of 0-10?μg/mL Phellamurin for 48 hours in U2OS and Saos-2?cells leads to a repression of cell viability dose-dependently, promotes the apoptosis of U2OS and Saos-2?cells concentration-dependently, and declines the ratios of p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR in U2OS and Saos-2?cells.(In Vivo):Intraperitoneal injection of 50?mg/kg/day Phellamurin daily for 21 days in female BALB/c nude mice represses osteosarcoma tumor growth in vivo. The ratios of p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR are decreased in xenograft in Phellamurin-treated mice.

Phellamurin (0-10?μg/mL; 48 hours; U2OS and Saos-2?cells) treatment leads to a repression of cell viability in U2OS and Saos-2?cells in a dose-dependent manner.Phellamurin (0-10?μg/mL; 48 hours; U2OS and Saos-2?cells) treatment concentration-dependently promots the apoptosis of U2OS and Saos-2?cells.Phellamurin (0-10?μg/mL; 48 hours; U2OS and Saos-2?cells) treatment declines the ratios of p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR in U2OS and Saos-2?cells. Cell Viability Assay Cell Line:U2OS and Saos-2?cells Concentration:0 μg/mL, 2.5 μg/mL, 5 μg/mL, and 10?μg/mL Incubation Time:48 hours Result:Suppressed the viability of U2OS and Saos-2?cells in a concentration-dependent manner.Apoptosis Analysis Cell Line:U2OS and Saos-2?cells Concentration:0 μg/mL, 2.5 μg/mL, 5 μg/mL, and 10?μg/mL Incubation Time:48 hours Result:Induced apoptosis of U2OS and Saos-2?cells in a concentration-dependent manner.Western Blot Analysis Cell Line:U2OS and Saos-2?cells Concentration:0 μg/mL and 10?μg/mL Incubation Time:48 hours Result:Repressed the PI3K/AKT/mTOR pathway in U2OS and Saos-2?cells.

Phellamurin (50?mg/kg/day; intraperitoneal injection; daily; for 21 days; female BALB/c nude mice) treatment represses osteosarcoma tumor growth in vivo. The ratios of p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR are decreased in xenograft in Phellamurin-treated mice. Animal Model:Athymic female BALB/c nude mice (6 weeks old ) injected with U2OS cells Dosage:50?mg/kg/day Administration:Intraperitoneal injection; daily; for 21 days Result:Repressed osteosarcoma tumor growth in vivo.

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Membrane Transporter/Ion Channel

P-glycoprotein

P-gp

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52589-11-4

518.51

C26H30O11

>98% (HPLC)

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CC(C)=CCc(c(O[C@@H]([C@H](C1=O)O)c(cc2)ccc2O)c1c(O)c1)c1O[C@@H]([C@@H]([C@H]1O)O)O[C@H](CO)[C@H]1O

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(-20℃)

With Ice Pack

≥ 2 years