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Home - Products - Membrane Transporter/Ion Channel - P-glycoprotein - Laniquidar

Laniquidar

CAS No. 197509-46-9

Laniquidar( R-101933 | R101933 )

Catalog No. M13087 CAS No. 197509-46-9

An orally active, third-generation P-glycoprotein inhibitor that inhibits the drug efflux pump P-glycoprotein.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Laniquidar
  • Note
    Research use only, not for human use.
  • Brief Description
    An orally active, third-generation P-glycoprotein inhibitor that inhibits the drug efflux pump P-glycoprotein.
  • Description
    An orally active, third-generation P-glycoprotein inhibitor that inhibits the drug efflux pump P-glycoprotein, resulting in higher concentrations of antineoplastic agents in tumor cells that are multi-drug resistant due to the overexpression of P-glycoprotein.Breast Cancer Phase 2.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    R-101933 | R101933
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    P-glycoprotein
  • Recptor
    P-glycoprotein
  • Research Area
    Cancer
  • Indication
    Breast Cancer

Chemical Information

  • CAS Number
    197509-46-9
  • Formula Weight
    584.7
  • Molecular Formula
    C37H36N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1=CN=C2N1CCC3=CC=CC=C3/C2=C4CCN(CCC5=CC=C(OCC6=NC7=CC=CC=C7C=C6)C=C5)CC\4)OC
  • Chemical Name
    methyl 11-(1-(4-(quinolin-2-ylmethoxy)phenethyl)piperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]imidazo[1,2-a]azepine-3-carboxylate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. van Zuylen L, et al. Clin Cancer Res. 2000 Apr;6(4):1365-71. 2. van Zuylen L, et al. Eur J Cancer. 2002 May;38(8):1090-9. 3. Luurtsema G, et al. Nucl Med Biol. 2009 Aug;36(6):643-9.
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