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Tariquidar
CAS No. 206873-63-4
Tariquidar( XR 9576 | XR-9576 | XR9576 )
Catalog No. M13215 CAS No. 206873-63-4
A potent, specific P-gp inhibitor with Kd of 5.1 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 41 | In Stock |
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| 10MG | 69 | In Stock |
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| 25MG | 119 | In Stock |
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| 50MG | 215 | In Stock |
|
| 100MG | 361 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTariquidar
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, specific P-gp inhibitor with Kd of 5.1 nM.
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DescriptionA potent, specific P-gp inhibitor with Kd of 5.1 nM; potentiates the cytotoxicity of several drugs including doxorubicin, paclitaxel, etoposide, and vincristine in a panel of human MDR cell lines at 25-80 nM; exhibits potent i.v. and p.o. activity without apparently enhancing the plasma pharmacokinetics of paclitaxel or the toxicity of coadministered drugs.Breast Cancer Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsXR 9576 | XR-9576 | XR9576
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PathwayMembrane Transporter/Ion Channel
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TargetP-glycoprotein
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RecptorP-gp?(P-glycoprotein)
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Research AreaCancer
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IndicationBreast Cancer
Chemical Information
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CAS Number206873-63-4
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Formula Weight646.7315
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Molecular FormulaC38H38N4O6
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 100 mg/mL
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SMILESCOC1=CC2=C(CN(CCC3=CC=C(NC(=O)C4=C(NC(=O)C5=CC6=CC=CC=C6N=C5)C=C(OC)C(OC)=C4)C=C3)CC2)C=C1OC |c:17,26,28,31,40,43,49,t:2,4,10,12,22,24,34|
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Chemical Name3-Quinolinecarboxamide, N-[2-[[[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]amino]carbonyl]-4,5-dimethoxyphenyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Martin C, et al. Br J Pharmacol. 1999 Sep;128(2):403-11.
2. Mistry P, et al. Cancer Res. 2001 Jan 15;61(2):749-58.
3. Walker J, et al. Eur J Cancer. 2004 Mar;40(4):594-605.
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Tariquidar
A potent, specific P-gp inhibitor with Kd of 5.1 nM.
