Nodosin

Research use only, not for human use.

Nodosin has an anti-inflammatory function via inhibition of IL-2. Nodosin perfusion provides a potential protective effect by inducing HO-1 expression to attenuate ischemia/reperfusion injury in liver transplantation.

Nodosin has an anti-inflammatory function via inhibition of IL-2. Nodosin perfusion provides a potential protective effect by inducing HO-1 expression to attenuate ischemia/reperfusion injury in liver transplantation.(In Vitro):In order to explore the anti-inflammatory effects of Nodosin from Isodon serra, a traditional Chinese herb medicine, mouse T lymphocytes were incubated with Nodosin.METHODS AND RESULTS: In the current study, Nodosin suppressed the overproduction of the T lymphocytes; moreover, the cell mitosis cycle was modulated by interfering with DNA replication in G1 stages via inhibition of IL-2 cytokine secretion at the mRNA level by Nodosin. Interestingly, Xylene-induced mouse tumescence model results suggested Nodosin depressed the murine ear-swelling extent and the level of IL-2 in the blood serum.

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Apoptosis

IL Receptor

IL Receptor

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10391-09-0

362.42

C20H26O6

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (344.90 mM)

CC1(C)CC[C@@]2([H])[C@@]3([C@]4([H])[C@H](O)C[C@@H]5C[C@@]4(C(O2)=O)C(C5=C)=O)[C@]1([H])[C@H](O)OC3

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(-20℃)

With Ice Pack

≥ 2 years