Ayanin

Research use only, not for human use.

Ayanin has vasorelaxant activity, it also may have the potential for use in treating allergic asthma. The IC50 value of Ayanin is 2.2microM for inhibiting interleukin IL-4 production from purified basophils. Ayanin is a non-selective phosphodiesterase1-4 inhibitor and can be used for respiratory disease researches.

Ayanin has vasorelaxant activity, it also may have the potential for use in treating allergic asthma. The IC50 value of Ayanin is 2.2microM for inhibiting interleukin IL-4 production from purified basophils. Ayanin is a non-selective phosphodiesterase1-4 inhibitor and can be used for respiratory disease researches.(In Vitro):Incubation of human leukemia cells with Ayanin diacetate induced G(2)-M phase cell cycle arrest and apoptosis which was prevented by the non-specific caspase inhibitor z-VAD-fmk and reduced by the overexpression of Bcl-x(L). Ayanin diacetate-induced cell death was found to be associated with: (i) loss of inner mitochondrial membrane potential, (ii) the release of cytochrome c, (iii) the activation of multiple caspases, (iv) cleavage of poly(ADP-ribose) polymerase and (v) the up-regulation of death receptors for TRAIL, DR4 and DR5. Moreover, the combined treatment with Ayanin diacetate and TRAIL amplified cell death, compared to single treatments.

Ayanin inhibits interleukin (IL)-4 production from purified basophils with an IC50 value of 2.2 μM.

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Apoptosis

IL Receptor

IL Receptor

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572-32-7

344.319

C18H16O7

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (726.07 mM)

COc1cc(O)c2c(c1)oc(-c1ccc(OC)c(O)c1)c(OC)c2=O

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(-20℃)

With Ice Pack

≥ 2 years