Nodosin( —— )

Catalog No. M29327 CAS No. 10391-09-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

Nodosin
Note

Research use only, not for human use.
Brief Description

Nodosin has an anti-inflammatory function via inhibition of IL-2. Nodosin perfusion provides a potential protective effect by inducing HO-1 expression to attenuate ischemia/reperfusion injury in liver transplantation.
Description

Nodosin has an anti-inflammatory function via inhibition of IL-2. Nodosin perfusion provides a potential protective effect by inducing HO-1 expression to attenuate ischemia/reperfusion injury in liver transplantation.(In Vitro):In order to explore the anti-inflammatory effects of Nodosin from Isodon serra, a traditional Chinese herb medicine, mouse T lymphocytes were incubated with Nodosin.METHODS AND RESULTS: In the current study, Nodosin suppressed the overproduction of the T lymphocytes; moreover, the cell mitosis cycle was modulated by interfering with DNA replication in G1 stages via inhibition of IL-2 cytokine secretion at the mRNA level by Nodosin. Interestingly, Xylene-induced mouse tumescence model results suggested Nodosin depressed the murine ear-swelling extent and the level of IL-2 in the blood serum.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Apoptosis
Target

IL Receptor
Recptor

IL Receptor
Research Area

——
Indication

——

CAS Number

10391-09-0
Formula Weight

362.42
Molecular Formula

C20H26O6
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (344.90 mM)
SMILES

CC1(C)CC[C@@]2([H])[C@@]3([C@]4([H])[C@H](O)C[C@@H]5C[C@@]4(C(O2)=O)C(C5=C)=O)[C@]1([H])[C@H](O)OC3
Chemical Name

——