
NGP555
CAS No. 1304630-27-0
NGP555( —— )
Catalog No. M23459 CAS No. 1304630-27-0
NGP555 is a modulator of γ-secretase.
Purity : >98% (HPLC)






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Biological Information
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Product NameNGP555
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NoteResearch use only, not for human use.
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Brief DescriptionNGP555 is a modulator of γ-secretase.
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DescriptionNGP555 is a modulator of γ-secretase.
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In VitroNGP555 potently lowers Aβ42 in cell cultures (9 nM) while increasing shorter forms of Aβ.
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In VivoNGP555 significantly lowers Aβ42 in the cerebrospinal fluid (CSF) at time points from 8 to10 hours post dose, panel B shows that reduction of Aβ cerebrospinal fluid (CSF) levels is significant at 3.75 mg/kg of NGP555 and above, and panel C shows an increase in Aβ38 levels at 15 mg/kg of NGP555 and above. When combining the reduction of Aβ42 with an increase in Aβ38, NGP555 is effective at raising CSF Aβ38/42 ratio at 1.87 mg/kg and above (panel D). NGP555-treated Tg mice show a significant protection from decline in performance with >65% less decline (P<0.005) when comparing the differential of Tg to non-Tg vehicle-treated mice. NGP555 also shows good oral bioavailability and is brain-penetrant with a brain:plasma ratio of ~0.93 in mice.
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Synonyms——
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PathwayNeuroscience
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TargetGamma-secretase
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Recptorγ secretase
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Research Area——
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Indication——
Chemical Information
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CAS Number1304630-27-0
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Formula Weight406.52
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Molecular FormulaC23H23FN4S
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Purity>98% (HPLC)
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SolubilityDMSO:25 mg/mL (61.50 mM; Need ultrasonic)
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SMILESCC1=CN(C2=CC=C(C3=CSC(NC4=CC(CC)=C(C)C=C4C)=N3)C=C2F)C=N1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Kounnas MZ, et al. NGP 555, a γ-Secretase Modulator, Lowers the Amyloid Biomarker, Aβ42, in Cerebrospinal Fluid while Preventing Alzheimer's Disease Cognitive Decline in Rodents. Alzheimers Dement (N Y). 2017 Jan;3(1):65-73.
molnova catalog



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