XPW1( —— )

Catalog No. M37124 CAS No. 2700286-66-2

XPW1 is a new potent and selective CDK9 inhibitor with antitumour activity that transcriptionally inhibits the DNA repair process in ccRCC cells.XPW1 can be used to study clear cell renal cell carcinoma.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

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Biological Information

Product Name

XPW1
Note

Research use only, not for human use.
Brief Description

XPW1 is a new potent and selective CDK9 inhibitor with antitumour activity that transcriptionally inhibits the DNA repair process in ccRCC cells.XPW1 can be used to study clear cell renal cell carcinoma.
Description

XPW1 is a potent and selective CDK9 inhibitor with excellent activity against clear cell renal cell carcinoma (ccRCC) and low toxicity.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Cell Cycle/DNA Damage
Target

CDK
Recptor

CDK
Research Area

——
Indication

——

Chemical Information

CAS Number

2700286-66-2
Formula Weight

656.19
Molecular Formula

C36H39ClFN7O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 31.25 mg/mL (47.62 mM; Ultrasonic (<60°C)
SMILES

ClC1=C(C=2N=C(NCC3=CC(F)=CC=C3)C=CC2)C=C(N[C@H]4CC[C@H](NC(=O)C5=CC=C(NC(/C=C/CN(C)C)=O)C=C5)CC4)N=C1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Kuang Z, et al. The novel CDK9 inhibitor, XPW1, alone and in combination with BRD4 inhibitor JQ1, for the treatment of clear cell renal cell carcinoma. Br J Cancer. 2023 Oct 26.?

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