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Brigimadlin
CAS No. 2095116-40-6
Brigimadlin( —— )
Catalog No. M36316 CAS No. 2095116-40-6
Brigimadlin (BI 907828) is an orally active and highly potent E3 ubiquitin-protein ligase
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 354 | In Stock |
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| 5MG | 272 | In Stock |
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| 10MG | 372 | In Stock |
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| 25MG | 611 | In Stock |
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| 50MG | 909 | In Stock |
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| 100MG | 1358 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBrigimadlin
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NoteResearch use only, not for human use.
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Brief DescriptionBrigimadlin (BI 907828) is an orally active and highly potent E3 ubiquitin-protein ligase
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DescriptionBrigimadlin (BI 907828) is an E3 ubiquitin-protein ligase MDM-2 inhibitor, preventing MDM-2 from negatively regulating the tumor suppressor p53. Brigimadlin can be used for antineoplastic research.
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In VitroCell Viability Assay Cell Line:BT48, BT50, BT67, BT69, BT89, BT94 Concentration:0-10 nM Incubation Time:48 h Result:IC50: 58.5, 21.1, 37.9, 89.8, 16.7, 46.8 pM.Western Blot Analysis Cell Line:BT48, BT67, BT73 cells Concentration:0-50 nM Incubation Time:48 h Result:Upregulated p21 and PUMA, and increased cleaved PARP level.
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetMDM2-p53
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RecptorMdm2 | p53
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Research Area——
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Indication——
Chemical Information
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CAS Number2095116-40-6
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Formula Weight591.46
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Molecular FormulaC31H25Cl2FN4O3
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Purity>98% (HPLC)
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Solubility——
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SMILESC(N1[C@@]2([C@H]([C@]3([C@@]1(CC=4N3N=C5C4C=CC(C(O)=O)=C5C)[H])[H])C6=C(F)C(Cl)=CC=C6)C=7C(NC2=O)=CC(Cl)=CC7)C8CC8
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gollner Andreas, et al. Preparation of spiroindolepyrrolidinone derivatives for use as MDM2-p53 inhibitors: World Intellectual Property Organization, WO2017060431. 2017-04-13.
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