Cart
sales@molnova.com
STIMA 1
CAS No. 91634-12-7
STIMA 1( STIMA1 )
Catalog No. M16581 CAS No. 91634-12-7
STIMA 1 is a small molecule mutant p53 reactivator that can stimulate mutant p53 DNA binding in vitro.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 29 | In Stock |
|
| 10MG | 38 | In Stock |
|
| 25MG | 55 | In Stock |
|
| 50MG | 101 | In Stock |
|
| 100MG | 153 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameSTIMA 1
-
NoteResearch use only, not for human use.
-
Brief DescriptionSTIMA 1 is a small molecule mutant p53 reactivator that can stimulate mutant p53 DNA binding in vitro.
-
DescriptionSTIMA 1 is a small molecule mutant p53 reactivator that can stimulate mutant p53 DNA binding in vitro, induces expression of p53 target proteins and triggers apoptosis in mutant p53-expressing human tumor cells.
-
In Vitro——
-
In Vivo——
-
SynonymsSTIMA1
-
PathwayApoptosis
-
TargetMDM2-p53
-
RecptorMDM2-p53
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number91634-12-7
-
Formula Weight172.187
-
Molecular FormulaC10H8N2O
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 250 mg/mL (1451.97 mM)
-
SMILESC=CC1=NC2=CC=CC=C2C(=O)N1
-
Chemical Name2-ethenyl-1H-quinazolin-4-one
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Zache N, et al. Mol Oncol. 2008 Jun;2(1):70-80.
2. Bykov VJ, et al. FEBS Lett. 2014 Aug 19;588(16):2622-7.
molnova catalog
related products
-
ISA27
ISA27 is a novel small molecule that blocks p53-MDM2 interaction and induces apoptosis both in vitro and in vivo.
-
P53R3
P53R3 is a novel p53 reactivator that restores sequence-specific DNA binding of the endogenously expressed p53(R175H) and p53(R273H) mutants in gel-shift assays.
-
Serdemetan
Serdemetan (JNJ 26854165) is a novel anticancer agent that inhibits the function of the E3 ligase HDM2.
