MB725( MB-725 )

Catalog No. M13572 CAS No. 2230058-99-6

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Product Name

MB725
Note

Research use only, not for human use.
Brief Description

MB725 is a small-molecule p53 mutant Y220C stabilizer, induces selective viability reduction in several p53-Y220C cancer cell lines (Huh7 cell IC50=10 uM).
Description

MB725 is a small-molecule p53 mutant Y220C stabilizer, induces selective viability reduction in several p53-Y220C cancer cell lines (Huh7 cell IC50=10 uM); reduction of viability correlated with increased and selective transcription of p53 target genes such as BTG2, p21, PUMA, FAS, TNF, and TNFRSF10B, which promote apoptosis and cell cycle arrest, suggesting compound-mediated transcriptional activation of the Y220C mutant.
In Vitro

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In Vivo

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Synonyms

MB-725
Pathway

Apoptosis
Target

MDM2-p53
Recptor

MDM2-p53
Research Area

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Indication

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CAS Number

2230058-99-6
Formula Weight

484.356
Molecular Formula

C18H21IN4O2S
Purity

>98% (HPLC)
Solubility

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SMILES

O=C(C1=C2N=C(N(CC)CC)SC2=C(N3C=CC=C3)C(I)=C1O)NCC
Chemical Name

2-(diethylamino)-N-ethyl-5-hydroxy-6-iodo-7-(1H-pyrrol-1-yl)benzo[d]thiazole-4-carboxamide

1. Baud MGJ, et al. Eur J Med Chem. 2018 May 25;152:101-114.

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