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MB725
CAS No. 2230058-99-6
MB725( MB-725 )
Catalog No. M13572 CAS No. 2230058-99-6
MB725 is a small-molecule p53 mutant Y220C stabilizer, induces selective viability reduction in several p53-Y220C cancer cell lines (Huh7 cell IC50=10 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1773 | Get Quote |
|
| 50MG | 3582 | Get Quote |
|
| 100MG | 4950 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameMB725
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NoteResearch use only, not for human use.
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Brief DescriptionMB725 is a small-molecule p53 mutant Y220C stabilizer, induces selective viability reduction in several p53-Y220C cancer cell lines (Huh7 cell IC50=10 uM).
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DescriptionMB725 is a small-molecule p53 mutant Y220C stabilizer, induces selective viability reduction in several p53-Y220C cancer cell lines (Huh7 cell IC50=10 uM); reduction of viability correlated with increased and selective transcription of p53 target genes such as BTG2, p21, PUMA, FAS, TNF, and TNFRSF10B, which promote apoptosis and cell cycle arrest, suggesting compound-mediated transcriptional activation of the Y220C mutant.
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In Vitro——
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In Vivo——
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SynonymsMB-725
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PathwayApoptosis
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TargetMDM2-p53
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RecptorMDM2-p53
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Research Area——
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Indication——
Chemical Information
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CAS Number2230058-99-6
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Formula Weight484.356
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Molecular FormulaC18H21IN4O2S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(C1=C2N=C(N(CC)CC)SC2=C(N3C=CC=C3)C(I)=C1O)NCC
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Chemical Name2-(diethylamino)-N-ethyl-5-hydroxy-6-iodo-7-(1H-pyrrol-1-yl)benzo[d]thiazole-4-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Baud MGJ, et al. Eur J Med Chem. 2018 May 25;152:101-114.
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