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SLMP53‐1
CAS No. 1643469-17-3
SLMP53‐1( —— )
Catalog No. M12501 CAS No. 1643469-17-3
A novel reactivator of wild-type and mutant p53, shows a p53-dependent anti-proliferative activity in human wt and mut p53R280K-expressing tumor cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 29 | In Stock |
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| 5MG | 297 | In Stock |
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| 10MG | 487 | In Stock |
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| 25MG | 938 | In Stock |
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| 50MG | 1535 | In Stock |
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| 100MG | 2465 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSLMP53‐1
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NoteResearch use only, not for human use.
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Brief DescriptionA novel reactivator of wild-type and mutant p53, shows a p53-dependent anti-proliferative activity in human wt and mut p53R280K-expressing tumor cells.
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DescriptionA novel reactivator of wild-type and mutant p53, shows a p53-dependent anti-proliferative activity in human wt and mut p53R280K-expressing tumor cells; enhances p53 transcriptional activity and restores wt-like DNA binding ability to mut p53R280K; inhibits the growth of wt/mut p53-expressing tumors in xenograft mice models, without apparent toxicity.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetMDM2-p53
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RecptorMDM2-p53
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Research Area——
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Indication——
Chemical Information
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CAS Number1643469-17-3
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Formula Weight318.376
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Molecular FormulaC20H18N2O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (785.25 mM)
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SMILES——
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Chemical Name(3S,9bR)-3-((1H-indol-3-yl)methyl)-9b-methyl-2,3-dihydrooxazolo[2,3-a]isoindol-5(9bH)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Soares J, et al. Oncotarget. 2016 Jan 26;7(4):4326-43.
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