MB710( MB-710 )

Catalog No. M13571 CAS No. 2230044-57-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MB710
Note

Research use only, not for human use.
Brief Description

MB710 is a small-molecule p53 mutant Y220C stabilizer, binds tightly to the Y220C pocket and stabilizes p53-Y220C in vitro.
Description

MB710 is a small-molecule p53 mutant Y220C stabilizer, binds tightly to the Y220C pocket and stabilizes p53-Y220C in vitro.
In Vitro

Cell Viability Assay Cell Line:NUGC3 (mutant p53 Y220C), HUH-7 (mutant p53 Y220C), NUGC4 (p53 WT), HUH-6 cells (p53 WT)Concentration:0-200 μM Incubation Time:72 hours Result:Showed relatively low toxicity against all cell lines tested at concentrations up to 60?μM. NUGC3 was the most sensitive cell line.
In Vivo

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Synonyms

MB-710
Pathway

Apoptosis
Target

MDM2-p53
Recptor

MDM2-p53
Research Area

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Indication

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CAS Number

2230044-57-0
Formula Weight

457.286
Molecular Formula

C16H16IN3O3S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 16.67 mg/mL (36.45 mM)
SMILES

O=C(C1=C2N=C(N(CC)CC)SC2=C(N3C=CC=C3)C(I)=C1O)O
Chemical Name

2-(diethylamino)-5-hydroxy-6-iodo-7-(1H-pyrrol-1-yl)benzo[d]thiazole-4-carboxylic acid

1. Baud MGJ, et al. Eur J Med Chem. 2018 May 25;152:101-114.

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