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MB710
CAS No. 2230044-57-0
MB710( MB-710 )
Catalog No. M13571 CAS No. 2230044-57-0
MB710 is a small-molecule p53 mutant Y220C stabilizer, binds tightly to the Y220C pocket and stabilizes p53-Y220C in vitro.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 519 | In Stock |
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| 5MG | 471 | In Stock |
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| 10MG | 827 | In Stock |
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| 25MG | 1767 | In Stock |
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| 50MG | 2771 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMB710
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NoteResearch use only, not for human use.
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Brief DescriptionMB710 is a small-molecule p53 mutant Y220C stabilizer, binds tightly to the Y220C pocket and stabilizes p53-Y220C in vitro.
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DescriptionMB710 is a small-molecule p53 mutant Y220C stabilizer, binds tightly to the Y220C pocket and stabilizes p53-Y220C in vitro.
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In VitroCell Viability Assay Cell Line:NUGC3 (mutant p53 Y220C), HUH-7 (mutant p53 Y220C), NUGC4 (p53 WT), HUH-6 cells (p53 WT)Concentration:0-200 μM Incubation Time:72 hours Result:Showed relatively low toxicity against all cell lines tested at concentrations up to 60?μM. NUGC3 was the most sensitive cell line.
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In Vivo——
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SynonymsMB-710
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PathwayApoptosis
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TargetMDM2-p53
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RecptorMDM2-p53
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Research Area——
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Indication——
Chemical Information
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CAS Number2230044-57-0
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Formula Weight457.286
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Molecular FormulaC16H16IN3O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 16.67 mg/mL (36.45 mM)
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SMILESO=C(C1=C2N=C(N(CC)CC)SC2=C(N3C=CC=C3)C(I)=C1O)O
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Chemical Name2-(diethylamino)-5-hydroxy-6-iodo-7-(1H-pyrrol-1-yl)benzo[d]thiazole-4-carboxylic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Baud MGJ, et al. Eur J Med Chem. 2018 May 25;152:101-114.
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