MI 219

Research use only, not for human use.

MI 219 is a potent, specific MDM2-p53 inhibitor with Ki of 5 nM, >10,000-fold selective for MDM2 over MDMX.

MI 219 is a potent, specific MDM2-p53 inhibitor with Ki of 5 nM, >10,000-fold selective for MDM2 over MDMX; disrupts the MDM2-p53 interaction and activates the p53 pathway in cells with wild-type p53, which leads to induction of cell cycle arrest in all cells and selective apoptosis in tumor cells; inhibits tumor growth in mouse xenograft models.

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MI219

Apoptosis

MDM2-p53

MDM2-p53

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908027-55-4

552.468

C27H32Cl2FN3O4

>98% (HPLC)

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O=C([C@H](N[C@@H]1CC(C)(C)C)[C@H](C2=CC=CC(Cl)=C2)[C@]31C(NC4=C3C=C(F)C(Cl)=C4)=O)NCC[C@H](O)CO

(2'R,3S,4'R,5'R)-6-Chloro-4'-(3-chlorophenyl)-N-[(3S)-3,4-dihydroxybutyl]-2'-(2,2-dimethylpropyl)-5-fluoro-1,2-dihydro-2-oxospiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide

(-20℃)

With Ice Pack

≥ 2 years