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JNJ-DGAT2-A
CAS No. 1962931-71-0
JNJ-DGAT2-A( —— )
Catalog No. M34299 CAS No. 1962931-71-0
JNJ-DGAT2-A, a specific inhibitor of DGAT2(IC50 = 0.14 μM), can be used in studies about the synthesis of triglycerides.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 155 | In Stock |
|
| 10MG | 275 | In Stock |
|
| 25MG | 549 | In Stock |
|
| 50MG | 775 | In Stock |
|
| 100MG | 1070 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 2130 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameJNJ-DGAT2-A
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NoteResearch use only, not for human use.
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Brief DescriptionJNJ-DGAT2-A, a specific inhibitor of DGAT2(IC50 = 0.14 μM), can be used in studies about the synthesis of triglycerides.
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DescriptionJNJ-DGAT2-A is a selective diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 value of 0.14 μM in human DGAT2-expressing Sf9 insect cell membranes. JNJ-DGAT2-A can be used for the research of triglyceride (TG) synthesis.
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In VitroJNJ-DGAT2-A (5 μM) inhibits about 99% of recombinant DGAT2 enzymatic activity.JNJ-DGAT2-A (5 μM) inhibits the DGAT activity in HepG2 cell lysates.JNJ-DGAT2-A (0.3125, 0.625, 1.25, 2.5, 5, 10, and 20 μM; 60 min prior to isotope-labeled and additional 2 h after isotope-labeled) dose-dependently inhibits the generation of TG (52:2), TG (54:3), and TG (50:2) using 13C3-D5-glycerol as a substrate in HepG2 cells with IC50 values of 0.85 μM, 0.99 μM, and 0.66 μM, respectively.
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetTransferase
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RecptorTransferase
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Research Area——
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Indication——
Chemical Information
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CAS Number1962931-71-0
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Formula Weight523.38
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Molecular FormulaC24H16BrFN4O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 3.33 mg/mL (6.36 mM; Ultrasonic (<60°C)
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SMILESFc1cc(\C=C2/SC(NCCc3ccccn3)=NC2=O)ccc1Oc1ccc(cc1Br)C#N
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Qi J, et al. The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2. J Lipid Res. 2012 Jun;53(6):1106-16.?
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