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Home - Products - Metabolic Enzyme/Protease - Transferase - FDW028

FDW028

CAS No. 2768426-49-7

FDW028( —— )

Catalog No. M37123 CAS No. 2768426-49-7

FDW028 is a selective and potent fucosyltransferase 8 (FUT8) inhibitor with anti-tumor activity that drives B7-H3 lysosomal degradation via defucosylation and CMA pathways. FUT8 can be used to study metastatic colorectal cancer (mCRC).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 161 In Stock
5MG 145 In Stock
10MG 227 In Stock
25MG 377 In Stock
50MG 535 In Stock
100MG 731 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    FDW028
  • Note
    Research use only, not for human use.
  • Brief Description
    FDW028 is a selective and potent fucosyltransferase 8 (FUT8) inhibitor with anti-tumor activity that drives B7-H3 lysosomal degradation via defucosylation and CMA pathways. FUT8 can be used to study metastatic colorectal cancer (mCRC).
  • Description
    FDW028 a potent and highly selective FUT8 inhibitor. FUT8 exhibits potent anti-tumor activity by defucosylation and impelling lysosomal degradation of B7-H3 through the chaperone-mediated autophagy (CMA) pathway. FDW028 can be used for metastatic colorectal cancer (mCRC) research.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Transferase
  • Recptor
    Transferase | Autophagy
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2768426-49-7
  • Formula Weight
    388.47
  • Molecular Formula
    C22H24N6O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (257.42 mM; Ultrasonic )
  • SMILES
    OC1=CC(=NC2=NC(=NN21)NCC3=CC=C(C=C3)CC)CNCC=4C=CC=CC4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wang M, et al. FDW028, a novel FUT8 inhibitor, impels lysosomal proteolysis of B7-H3 via chaperone-mediated autophagy pathway and exhibits potent efficacy against metastatic colorectal cancer. Cell Death Dis. 2023 Aug 3;14(8):495.?
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