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G43
CAS No. 690693-02-8
G43( —— )
Catalog No. M37004 CAS No. 690693-02-8
G43 is a potent and selective glucosyltransferase inhibitor that inhibits GtfB and GtfC with Kd values of 3.7 μM and 46.9 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 174 | In Stock |
|
| 5MG | 172 | In Stock |
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| 10MG | 254 | In Stock |
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| 25MG | 392 | In Stock |
|
| 50MG | 531 | In Stock |
|
| 100MG | 710 | In Stock |
|
| 200MG | 958 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameG43
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NoteResearch use only, not for human use.
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Brief DescriptionG43 is a potent and selective glucosyltransferase inhibitor that inhibits GtfB and GtfC with Kd values of 3.7 μM and 46.9 nM, respectively.
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DescriptionG43 is a potent, selective glucosyltransferaseinhibitor, with the Kd of 3.7μM and 46.9 nM for GtfB and GtfC, respectively. G43 has antibacterial to S. mutans in vitro and in vivo, and can be used for dental caries study.
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In VitroRT-PCR Cell Line:S. mutans. UA159 cells Concentration:3.125, 6.25, 12, 25 μM Incubation Time:24 h Result:Showed no significant difference on expression of gtfs (gtfB, gtfC and gtfD).
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In VivoAnimal Model:The rat model of dental caries infected with S. mutans UA159 Dosage:100?μM twice daily for 4 weeks Administration:Topically administration Result:Reduced the buccal, sulcal, and proximal surface caries scores, but did not lose weight over the course of the study.
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetTransferase
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RecptorTransferase | Antibacterial
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Research Area——
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Indication——
Chemical Information
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CAS Number690693-02-8
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Formula Weight341.34
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Molecular FormulaC16H11N3O4S
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Purity>98% (HPLC)
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Solubility——
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SMILESC(NC1=C(C(N)=O)C=CC=C1)(=O)C2=CC=3C(S2)=CC=C(N(=O)=O)C3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhang Q, et al. Structure-Based Discovery of Small Molecule Inhibitors of Cariogenic Virulence. Sci Rep. 2017;7(1):5974.?
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