G43( —— )

Catalog No. M37004 CAS No. 690693-02-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

G43
Note

Research use only, not for human use.
Brief Description

G43 is a potent and selective glucosyltransferase inhibitor that inhibits GtfB and GtfC with Kd values of 3.7 μM and 46.9 nM, respectively.
Description

G43 is a potent, selective glucosyltransferaseinhibitor, with the Kd of 3.7μM and 46.9 nM for GtfB and GtfC, respectively. G43 has antibacterial to S. mutans in vitro and in vivo, and can be used for dental caries study.
In Vitro

RT-PCR Cell Line:S. mutans. UA159 cells Concentration:3.125, 6.25, 12, 25 μM Incubation Time:24 h Result:Showed no significant difference on expression of gtfs (gtfB, gtfC and gtfD).
In Vivo

Animal Model:The rat model of dental caries infected with S. mutans UA159 Dosage:100?μM twice daily for 4 weeks Administration:Topically administration Result:Reduced the buccal, sulcal, and proximal surface caries scores, but did not lose weight over the course of the study.
Synonyms

——
Pathway

Metabolic Enzyme/Protease
Target

Transferase
Recptor

Transferase | Antibacterial
Research Area

——
Indication

——

1. Zhang Q, et al. Structure-Based Discovery of Small Molecule Inhibitors of Cariogenic Virulence. Sci Rep. 2017;7(1):5974.?

Calculator

molnova catalog