Phox-I2( —— )

Catalog No. M34115 CAS No. 353495-22-4

Phox-I2 is an NOX2-specific inhibitor. Phox-I2 reverts ROS-accumulation and leads to refusion of mitochondrial networks.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
2MG	117	Get Quote
5MG	188	Get Quote
10MG	282	Get Quote
25MG	453	Get Quote
50MG	660	Get Quote
100MG	889	Get Quote
500MG	1782	Get Quote
1G	Get Quote	Get Quote

Get Quotation Bulk Inquiry Add to Cart

Biological Information

Product Name

Phox-I2
Note

Research use only, not for human use.
Brief Description

Phox-I2 is an NOX2-specific inhibitor. Phox-I2 reverts ROS-accumulation and leads to refusion of mitochondrial networks.
Description

Phox-I2 is a selective inhibitor of p67phox-Rac1 interaction, binds to p67phox with high affinity with a Kd of ~150 nM. Phox-I2 is a NADPH oxidase 2 (NOX2) inhibitor and inhibits reactive oxygen species (ROS) production.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Membrane Transporter/Ion Channel
Target

NADPH
Recptor

NADPH-oxidase
Research Area

——
Indication

——

Chemical Information

CAS Number

353495-22-4
Formula Weight

337.33
Molecular Formula

C18H15N3O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (741.11 mM; Ultrasonic )
SMILES

[O-][N+](=O)c1cccc(c1)C1Nc2ccc(cc2C2C=CCC12)[N+]([O-])=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Emily E Bosco, et al. Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation. Chem Biol. 2012 Feb 24;19(2):228-42.?

Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog

Product			Quantity Required*
Name *			E-mail Address *
Organization *			Phone Number
Remarks