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Phox-I2

CAS No. 353495-22-4

Phox-I2( —— )

Catalog No. M34115 CAS No. 353495-22-4

Phox-I2 is an NOX2-specific inhibitor. Phox-I2 reverts ROS-accumulation and leads to refusion of mitochondrial networks.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 231 In Stock
5MG 188 In Stock
10MG 282 In Stock
25MG 467 In Stock
50MG 667 In Stock
100MG 919 In Stock
200MG Get Quote In Stock
500MG 1841 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Phox-I2
  • Note
    Research use only, not for human use.
  • Brief Description
    Phox-I2 is an NOX2-specific inhibitor. Phox-I2 reverts ROS-accumulation and leads to refusion of mitochondrial networks.
  • Description
    Phox-I2 is a selective inhibitor of p67phox-Rac1 interaction, binds to p67phox with high affinity with a Kd of ~150 nM. Phox-I2 is a NADPH oxidase 2 (NOX2) inhibitor and inhibits reactive oxygen species (ROS) production.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    NADPH
  • Recptor
    NADPH-oxidase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    353495-22-4
  • Formula Weight
    337.33
  • Molecular Formula
    C18H15N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (741.11 mM; Ultrasonic )
  • SMILES
    [O-][N+](=O)c1cccc(c1)C1Nc2ccc(cc2C2C=CCC12)[N+]([O-])=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Emily E Bosco, et al. Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation. Chem Biol. 2012 Feb 24;19(2):228-42.?
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