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GLX351322

CAS No. 835598-94-2

GLX351322( —— )

Catalog No. M21200 CAS No. 835598-94-2

GLX351322 is NADPH Oxidase 4 Inhibitor with IC50 of 5 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 126 In Stock
2MG 40 In Stock
5MG 65 In Stock
10MG 106 In Stock
25MG 242 In Stock
50MG 405 In Stock
100MG 602 In Stock
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Biological Information

  • Product Name
    GLX351322
  • Note
    Research use only, not for human use.
  • Brief Description
    GLX351322 is NADPH Oxidase 4 Inhibitor with IC50 of 5 μM.
  • Description
    GLX351322 is NADPH Oxidase 4 Inhibitor with IC50 of 5 μM.
  • In Vitro
    GLX351322 is an inhibitor of NADPH oxidase 4, and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μM. GLX351322 shows weak activity against NOX2 in hPBMC cells (IC50, 40 μM).
  • In Vivo
    GLX351322 (3.8 mg/kg/day, p.o.) ameliorates HFD-induced hyperglycemia in mice.
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    NADPH
  • Recptor
    NOX4
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    835598-94-2
  • Formula Weight
    431.5
  • Molecular Formula
    C21H25N3O5S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:20 mg/mL (46.35 mM; Need ultrasonic)
  • SMILES
    CCOC(=O)c1c(NC(=O)CN2CCN(C(=O)c3ccco3)CC2)sc2c1CCC2
  • Chemical Name
    Ethyl 2-[[2-[4-(furan-2-carbonyl)piperazin-1-yl]acetyl]amino]-56-dihydro-4H-cyclopenta-[b]thiophene-3-carboxylate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Anvari Ebrahim Wikstr?m Per Walum Eriket al. The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice[J]. Free Radical Research 49(11):1-32.
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