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GLX351322

CAS No. 835598-94-2

GLX351322( —— )

Catalog No. M21200 CAS No. 835598-94-2

GLX351322 is NADPH Oxidase 4 Inhibitor with IC50 of 5 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 126 In Stock
2MG 40 In Stock
5MG 65 In Stock
10MG 106 In Stock
25MG 242 In Stock
50MG 405 In Stock
100MG 602 In Stock
200MG Get Quote In Stock
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Biological Information

  • Product Name
    GLX351322
  • Note
    Research use only, not for human use.
  • Brief Description
    GLX351322 is NADPH Oxidase 4 Inhibitor with IC50 of 5 μM.
  • Description
    GLX351322 is NADPH Oxidase 4 Inhibitor with IC50 of 5 μM.
  • In Vitro
    GLX351322 is an inhibitor of NADPH oxidase 4, and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μM. GLX351322 shows weak activity against NOX2 in hPBMC cells (IC50, 40 μM).
  • In Vivo
    GLX351322 (3.8 mg/kg/day, p.o.) ameliorates HFD-induced hyperglycemia in mice.
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    NADPH
  • Recptor
    NOX4
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    835598-94-2
  • Formula Weight
    431.5
  • Molecular Formula
    C21H25N3O5S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:20 mg/mL (46.35 mM; Need ultrasonic)
  • SMILES
    CCOC(=O)c1c(NC(=O)CN2CCN(C(=O)c3ccco3)CC2)sc2c1CCC2
  • Chemical Name
    Ethyl 2-[[2-[4-(furan-2-carbonyl)piperazin-1-yl]acetyl]amino]-56-dihydro-4H-cyclopenta-[b]thiophene-3-carboxylate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Anvari Ebrahim Wikstr?m Per Walum Eriket al. The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice[J]. Free Radical Research 49(11):1-32.
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