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2-HBA
CAS No. 131359-24-5
2-HBA( —— )
Catalog No. M20833 CAS No. 131359-24-5
2-HBA a synthetic analog of curcumin is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 50 | In Stock |
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| 2MG | 29 | In Stock |
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| 5MG | 46 | In Stock |
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| 10MG | 69 | In Stock |
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| 25MG | 140 | In Stock |
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| 50MG | 220 | In Stock |
|
| 100MG | 352 | In Stock |
|
| 200MG | 520 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product Name2-HBA
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NoteResearch use only, not for human use.
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Brief Description2-HBA a synthetic analog of curcumin is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway.
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Description2-HBA a synthetic analog of curcumin is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway.
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In VitroWhen L1210 cells are exposed to 0.6 μM 2-HBA (bis(2-hydroxy-benzylidene)acetone), the specific activities of NQO1 and glutathione reductase increase by 6- and 1.5-fold, respectively. The total cellular glutathione content is also coordinately induced by 2.4-fold. In a more detailed study it is found that NQO1 is induced by 2-HBA in a concentration-dependent manner. Treatments with 2-HBA cause cell cycle arrest and apoptosis in both L1210 wild type cells and their Y8 drug-resistant counterparts in a concentration-dependent manner. 2-HBA can also activate caspase-3 and caspase-10.
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In Vivo——
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetNADPH
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RecptorNQO1|Caspase
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Research Area——
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Indication——
Chemical Information
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CAS Number131359-24-5
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Formula Weight266.29
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Molecular FormulaC17H14O3
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Purity>98% (HPLC)
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SolubilityDMSO:100 mg/mL (375.53 mM)
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SMILESO=C(/C=C/c1ccccc1O)/C=C/c1ccccc1O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Dinkova-Kostova A T Cory A H Bozak R E et al. Bis(2-hydroxybenzylidene)acetone a potent inducer of the phase 2 response causes apoptosis in mouse leukemia cells through a p53-independent caspase-mediated pathway[J]. Cancer Letters 2007 245(1-2):0-349.
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