Cart
sales@molnova.com
VU 0285683
CAS No. 327056-22-4
VU 0285683( —— )
Catalog No. M33945 CAS No. 327056-22-4
VU 0285683 is a specific negative allosteric modulator of mGluR5 with a high affinity for the MPEP binding site. VU 0285683 shows anxiolytic-like activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 62 | In Stock |
|
| 2MG | 33 | In Stock |
|
| 5MG | 55 | In Stock |
|
| 10MG | 68 | In Stock |
|
| 25MG | 115 | In Stock |
|
| 50MG | 161 | In Stock |
|
| 100MG | 230 | In Stock |
|
| 200MG | 312 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameVU 0285683
-
NoteResearch use only, not for human use.
-
Brief DescriptionVU 0285683 is a specific negative allosteric modulator of mGluR5 with a high affinity for the MPEP binding site. VU 0285683 shows anxiolytic-like activity.
-
DescriptionVU0285683 is a selective mGluR5 positive allosteric modulator (PAM).VU0285683 has anxiolytic-like activity in rodent models for anxiety.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayNeuroscience
-
TargetGluR
-
RecptorGluR
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number327056-22-4
-
Formula Weight266.23
-
Molecular FormulaC14H7FN4O
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC(#N)C=1C=C(C=C(F)C1)C2=NC(=NO2)C3=CC=CC=N3
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Alice L Rodriguez, et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol Pharmacol. 2010 Dec;78(6):1105-23. ?
molnova catalog
related products
-
LY404187
LY404187 is a positive allosteric modulator of AMPA receptors.
-
HBT1
HBT1 is an AMPA receptor potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons. HBT1 binds to ligand-binding domain of AMPA-R in glutamate dependent manner.HBT1 bound to the ligand-binding domain (LBD) of AMPA-R in a glutamate-dependent manner.?
-
LY-2300559
LY-2300559 is an agonist of metabotropic glutamate receptor 2 (mGluR2) and can be used in studies about the treatment of migraine.
