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VU 0285683

CAS No. 327056-22-4

VU 0285683( —— )

Catalog No. M33945 CAS No. 327056-22-4

VU 0285683 is a specific negative allosteric modulator of mGluR5 with a high affinity for the MPEP binding site. VU 0285683 shows anxiolytic-like activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 62 In Stock
2MG 33 In Stock
5MG 55 In Stock
10MG 68 In Stock
25MG 115 In Stock
50MG 161 In Stock
100MG 230 In Stock
200MG 312 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    VU 0285683
  • Note
    Research use only, not for human use.
  • Brief Description
    VU 0285683 is a specific negative allosteric modulator of mGluR5 with a high affinity for the MPEP binding site. VU 0285683 shows anxiolytic-like activity.
  • Description
    VU0285683 is a selective mGluR5 positive allosteric modulator (PAM).VU0285683 has anxiolytic-like activity in rodent models for anxiety.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Neuroscience
  • Target
    GluR
  • Recptor
    GluR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    327056-22-4
  • Formula Weight
    266.23
  • Molecular Formula
    C14H7FN4O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(#N)C=1C=C(C=C(F)C1)C2=NC(=NO2)C3=CC=CC=N3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Alice L Rodriguez, et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol Pharmacol. 2010 Dec;78(6):1105-23. ?
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