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DNQX

CAS No. 2379-57-9

DNQX( FG 9041 )

Catalog No. M20669 CAS No. 2379-57-9

DNQX is a competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors respectively).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 48 In Stock
25MG 48 In Stock
50MG 76 In Stock
100MG 109 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    DNQX
  • Note
    Research use only, not for human use.
  • Brief Description
    DNQX is a competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors respectively).
  • Description
    DNQX is a competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors respectively).
  • In Vitro
    DNQX selectively depolarizes thalamic reticular nucleus (TRN) neurons.
  • In Vivo
    DNQX, a specific AMPA receptor antagonist, given as either a 5 mg/kg or 10 mg/kg intraperitoneal dose or into the lateral cerebral ventricle (5 μl of 0.5 mg/ml) significantly diminishes phencyclidine (PCP) (40 mg/kg) and ketamine (80, 100, 120 mg/kg) hsp70 induction in the posterior cingulate and retrosplenial cortex.
  • Synonyms
    FG 9041
  • Pathway
    Neuroscience
  • Target
    GluR
  • Recptor
    AMPA
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2379-57-9
  • Formula Weight
    252.14
  • Molecular Formula
    C8H4N4O6
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:35 mg/mL (138.81 mM)
  • SMILES
    [O-][N+](=O)c1cc2[nH]c(=O)c(=O)[nH]c2cc1[N+]([O-])=O
  • Chemical Name
    67-Dinitroquinoxaline-23(1H4H)-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Muller D Joly M Lynch G . Contributions of quisqualate and NMDA receptors to the induction and expression of LTP[J]. Science 1988 242(4886):1694-1697.
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