(E/Z)-SIB-1893( —— )

Catalog No. M33927 CAS No. 6266-99-5

(E/Z)-SIB-1893 (SIB 1893) is the racemate of (E)-SIB-1893 and (Z)-SIB-1893. (E)-SIB-1893 is a selective, noncompetitive mGluR5 antagonist with anticonvulsant activity .

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

(E/Z)-SIB-1893
Note

Research use only, not for human use.
Brief Description

(E/Z)-SIB-1893 (SIB 1893) is the racemate of (E)-SIB-1893 and (Z)-SIB-1893. (E)-SIB-1893 is a selective, noncompetitive mGluR5 antagonist with anticonvulsant activity .
Description

(E/Z)-SIB-1893 is a racemic compound of (E)-SIB-1893 and (Z)-SIB-1893 isomers. (E)-SIB-1893 is a selective non-competitive metabotropic glutamate subtype 5 receptor (mGluR5) antagonist.
In Vitro

——
In Vivo

(E)-SIB-1893 produces hypothermia in freely moving rats in a dose-dependent manner.
Synonyms

——
Pathway

Neuroscience
Target

GluR
Recptor

GluR
Research Area

——
Indication

——

Chemical Information

CAS Number

6266-99-5
Formula Weight

195.26
Molecular Formula

C14H13N
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (512.14 mM; Ultrasonic )
SMILES

C(=CC1=CC=CC=C1)C=2N=C(C)C=CC2
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. ?uszczki JJ, et al. Non-competitive metabotropic glutamate subtype 5 receptor antagonist (SIB-1893) decreases body temperature in rats. Pharmacol Rep. 2005;57(6):795-801.?

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