Cart
sales@molnova.com
NPS2390
CAS No. 226878-01-9
NPS2390( —— )
Catalog No. M21958 CAS No. 226878-01-9
NPS2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50 of 5.2 and 82 nM, respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 44 | In Stock |
|
| 5MG | 33 | In Stock |
|
| 10MG | 55 | In Stock |
|
| 25MG | 107 | In Stock |
|
| 50MG | 183 | In Stock |
|
| 100MG | 300 | In Stock |
|
| 200MG | 414 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameNPS2390
-
NoteResearch use only, not for human use.
-
Brief DescriptionNPS2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50 of 5.2 and 82 nM, respectively).
-
DescriptionNPS2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50 of 5.2 and 82 nM, respectively). Treatment of NPS2390 was conducive to inhibit the proliferation and reverse phenotypic modulation of PASMCs by regulating autophagy levels.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayNeuroscience
-
TargetGluR
-
RecptormGluR
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number226878-01-9
-
Formula Weight307.4
-
Molecular FormulaC19H21N3O
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 6.25 mg/mL (20.33 mM)
-
SMILESO=C(NC12CC3CC(CC(C3)C1)C2)c1cnc2ccccc2n1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Peng X , Wei C , Li H Z , et al. NPS2390, a Selective Calcium-sensing Receptor Antagonist Controls the Phenotypic Modulation of Hypoxic Human Pulmonary Arterial Smooth Muscle Cells by Regulating Autophagy[J]. Journal of Translational Internal Medicine, 2019, 7(2):59-68.
molnova catalog
related products
-
Chelidamic acid
Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid is inhibitors of glutamate decarboxylase with a Ki of 33 μM.
-
DMeOB
DMeOB (3,3'-Dimethoxybenzaldazine) is a negative regulator with mGluR5 agonist activity and can be used to study neurological diseases.
-
1-ethyl-3-morpholin-...
1-ethyl-3-morpholin-4-yl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile is a positive allosteric modulator of mGluR3 and can be used in studies about the treatment of Parkinson's disease.
