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Fangchinoline
CAS No. 436-77-1
Fangchinoline( —— )
Catalog No. M17509 CAS No. 436-77-1
Fangchinoline is extracted from Stephania tetrandra S. Moore.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 51 | In Stock |
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| 5MG | 38 | In Stock |
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| 10MG | 59 | In Stock |
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| 25MG | 92 | In Stock |
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| 50MG | 129 | In Stock |
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| 100MG | 198 | In Stock |
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| 200MG | 296 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameFangchinoline
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NoteResearch use only, not for human use.
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Brief DescriptionFangchinoline is extracted from Stephania tetrandra S. Moore.
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DescriptionFangchinoline is extracted from Stephania tetrandra S. Moore.(In Vitro):Fangchinoline (2.5-40 μM; 24-96 hours) inhibits both T24 and 5637 cells in dose-dependent manner, the IC50 values of Fangchinoline in T24 cells are 19.0 μM (24 h), 12.0 μM (48 h) and 7.57 μM (72 h), and 11.9 μM (24 h), 9.92 μM (48 h) and 7.13 μM (72 h) in 5637 cells.Fangchinoline (5 μM; 24 hours) induces a significant increase in the LC3-II/LC3-I ratio and a decrease in p62 in both T24 and 5637 cells, and causes a significant increase in the cleavage of caspase-3.
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In VitroFangchinoline (2.5-40 μM; 24-96 hours) inhibits both T24 and 5637 cells in dose-dependent manner, the IC50 values of Fangchinoline in T24 cells are 19.0 μM (24 h), 12.0 μM (48 h) and 7.57 μM (72 h), and 11.9 μM (24 h), 9.92 μM (48 h) and 7.13 μM (72 h) in 5637 cells.Fangchinoline (5 μM; 24 hours) induces a significant increase in the LC3-II/LC3-I ratio and a decrease in p62 in both T24 and 5637 cells, and causes a significant increase in the cleavage of caspase-3. Cell Viability AssayCell Line:T24 and 5637 cells Concentration:2.5 μM; 5 μM; 10 μM; 20 μM; 30 μM; 40 μM Incubation Time:24 hours; 48 hours; 96 hours Result:Inhibited both T24 and 5637 cells proliferation.Western Blot Analysis Cell Line:T24 and 5637 cells Concentration:5 μM Incubation Time:24 hours Result:Incresed LC3-II/LC3-I ratio and the cleavage of caspase-3.
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In Vivo——
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Synonyms——
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PathwayNeuroscience
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TargetGluR
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RecptorFAK
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Research AreaOthers-Field
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Indication——
Chemical Information
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CAS Number436-77-1
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Formula Weight608.72
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Molecular FormulaC37H40N2O6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (82.14 mM)
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SMILESO1c2c3[C@@H](N(CCc3cc(OC)c2O)C)Cc2cc(Oc3ccc(C[C@@H]4N(CCc5c4cc1c(OC)c5)C)cc3)c(OC)cc2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Basimglurant
Basimglurant is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM). In competition binding experiments on human recombinant mGlu5, Basimglurant (RG7090) fully displaces [3H]-MPEP with a Ki of 35.6 nM and [3H]-ABP688 with a Ki of 1.4 nM. In HEK293 cells stably expressing human mGlu5, Basimglurant (RG7090) inhibits quisqualate induced Ca2+ mobilization with an IC50 of 7.0 nM and [3H]-inositolphosphate accumulation (IC50 of 5.9 nM).
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KM02894
KM02894 is a glutamate release inhibitor. Cancer cells release high levels of glutamate that can disrupt normal bone turnover, which can lead to cancer-induced bone pain.KM02894 may be used in the study of tumor-related diseases.
