Fangchinoline

Research use only, not for human use.

Fangchinoline is extracted from Stephania tetrandra S. Moore.

Fangchinoline is extracted from Stephania tetrandra S. Moore.(In Vitro):Fangchinoline (2.5-40 μM; 24-96 hours) inhibits both T24 and 5637 cells in dose-dependent manner, the IC50 values of Fangchinoline in T24 cells are 19.0 μM (24 h), 12.0 μM (48 h) and 7.57 μM (72 h), and 11.9 μM (24 h), 9.92 μM (48 h) and 7.13 μM (72 h) in 5637 cells.Fangchinoline (5 μM; 24 hours) induces a significant increase in the LC3-II/LC3-I ratio and a decrease in p62 in both T24 and 5637 cells, and causes a significant increase in the cleavage of caspase-3.

Fangchinoline (2.5-40 μM; 24-96 hours) inhibits both T24 and 5637 cells in dose-dependent manner, the IC50 values of Fangchinoline in T24 cells are 19.0 μM (24 h), 12.0 μM (48 h) and 7.57 μM (72 h), and 11.9 μM (24 h), 9.92 μM (48 h) and 7.13 μM (72 h) in 5637 cells.Fangchinoline (5 μM; 24 hours) induces a significant increase in the LC3-II/LC3-I ratio and a decrease in p62 in both T24 and 5637 cells, and causes a significant increase in the cleavage of caspase-3. Cell Viability AssayCell Line:T24 and 5637 cells Concentration:2.5 μM; 5 μM; 10 μM; 20 μM; 30 μM; 40 μM Incubation Time:24 hours; 48 hours; 96 hours Result:Inhibited both T24 and 5637 cells proliferation.Western Blot Analysis Cell Line:T24 and 5637 cells Concentration:5 μM Incubation Time:24 hours Result:Incresed LC3-II/LC3-I ratio and the cleavage of caspase-3.

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Neuroscience

GluR

FAK

Others-Field

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436-77-1

608.72

C37H40N2O6

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (82.14 mM)

O1c2c3[C@@H](N(CCc3cc(OC)c2O)C)Cc2cc(Oc3ccc(C[C@@H]4N(CCc5c4cc1c(OC)c5)C)cc3)c(OC)cc2

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(-20℃)

With Ice Pack

≥ 2 years