Cart
sales@molnova.com
Home - Products - PI3K/Akt/mTOR signaling - PDK - M77976

M77976

CAS No. 394237-61-7

M77976( —— )

Catalog No. M33422 CAS No. 394237-61-7

M77976 is a selective ATP-competitive inhibitor of pyruvate dehydrogenase kinase 4 (PDK4) with an inhibitory effect on PDK4, having an IC50 value of 648 μM. It is used for research related to obesity and diabetes.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 59 Get Quote
5MG 85 Get Quote
10MG 140 Get Quote
25MG 266 Get Quote
50MG 403 Get Quote
100MG 620 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    M77976
  • Note
    Research use only, not for human use.
  • Brief Description
    M77976 is a selective ATP-competitive inhibitor of pyruvate dehydrogenase kinase 4 (PDK4) with an inhibitory effect on PDK4, having an IC50 value of 648 μM. It is used for research related to obesity and diabetes.
  • Description
    M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms 4), with an IC50 of 648 μM. M77976 is potential for the research of obesity and diabetes.
  • In Vitro
    M77976 binds to the ATP-binding pocket of PDK4 and causes local conformational changes with complete disordering of the ATP lid.M77976 makes hydrophobic interactions with the side chains of Asn258, Ala262, Val298, Leu306 and Thr358 of PDK4.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    PDK
  • Recptor
    PDK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    394237-61-7
  • Formula Weight
    296.32
  • Molecular Formula
    C17H16N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (843.68 mM; Ultrasonic )
  • SMILES
    COc1ccc(cc1)-c1c(C)[nH]nc1-c1ccc(O)cc1O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kukimoto-Niino M, et al. Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4. Acta Crystallogr D Biol Crystallogr. 2011 Sep;67(Pt 9):763-73.?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • PS 210

    PS 210 is a potent, specific activator of PDK1 that target the PIF-binding pocket of PDK1.

  • RS1-PDK1 inhibitor

    RS1-PDK1 inhibitor (RS 1) is a selective inhibitor of the protein kinase PDK1 that can be used to treat and prevent disease or disorders.

  • BX-320

    BX-320 is a potent, selective and ATP-competitive inhibitor of PDK1 with IC50 of 30 nM.

Sign In Join Free