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VER-246608

CAS No. 1684386-71-7

VER-246608( —— )

Catalog No. M23757 CAS No. 1684386-71-7

VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 132 In Stock
2MG 65 In Stock
5MG 107 In Stock
10MG 169 In Stock
25MG 330 In Stock
50MG 491 In Stock
100MG 715 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    VER-246608
  • Note
    Research use only, not for human use.
  • Brief Description
    VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase.
  • Description
    VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively).VER-246608 disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells. Consistent with a PDK mediated MOA, VER-246608 increased pyruvate dehydrogenase complex (PDC) activity, oxygen consumption and attenuated glycolytic activity. VER-246608 was found to potentiate the activity of doxorubicin.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    PDK
  • Recptor
    PDK1|PDK2|PDK3|PDK4
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1684386-71-7
  • Formula Weight
    552.96
  • Molecular Formula
    C28H23ClF2N4O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:100 mg/mL (180.84 mM; Need ultrasonic)
  • SMILES
    O=C(C1=CC=C(O)C=C1O)N(CC2=CC=C(CNC(C(F)F)=O)C=C2)C(C=C3)=CC=C3C4=NC(Cl)=NC=C4C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Moore JD, et al. VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells. Oncotarget. 2014 Dec 30;5(24):12862-76.
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