PS 210( PS210 )

Catalog No. M10840 CAS No. 1221962-86-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

PS 210
Note

Research use only, not for human use.
Brief Description

PS 210 is a potent, specific activator of PDK1 that target the PIF-binding pocket of PDK1.
Description

PS 210 is a potent, specific activator of PDK1 that target the PIF-binding pocket of PDK1, does not alter the activity of any of the 121 kinases (S6K, PKB/Akt or GSK3).
In Vitro

When PS210 induces a stabilization of PDK1 to the temperature gradien, PS210 stabilized the residue Arg131, located opposite to the helix a-B at the other extreme of the helix a-C. Thus, the residues forming part of the phosphate-binding site appear to be a fixed point that allows for the relative movement of the helices in the process of PDK1 activation.
In Vivo

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Synonyms

PS210
Pathway

PI3K/Akt/mTOR signaling
Target

PDK
Recptor

PDK
Research Area

——
Indication

——

CAS Number

1221962-86-2
Formula Weight

380.319
Molecular Formula

C19H15F3O5
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (262.94 mM)
SMILES

O=C(O)C(C(C1=CC=CC=C1)CC(C2=CC=C(C(F)(F)F)C=C2)=O)C(O)=O
Chemical Name

2-(3-oxo-1-phenyl-3-(4-(trifluoromethyl)phenyl)propyl)malonic acid

1. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14. 2. Busschots K, et al. Chem Biol. 2012 Sep 21;19(9):1152-63.

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