PS 423( PS423 )

Catalog No. M10841 CAS No. 1221964-37-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

PS 423
Note

Research use only, not for human use.
Brief Description

PS 423 is a substrate-selective inhibitor of PDK1, inhibits the phosphorylation and activation of S6K.
Description

PS 423 is a substrate-selective inhibitor of PDK1, inhibits the phosphorylation and activation of S6K without affecting the PKB/Akt signaling pathway in HEK293 cells, the prodrug of PS210; inhibits glucose uptake in C2C12 myoblasts; inhibits S6K but not PKB/Akt downstream signaling in muscle cells.
In Vitro

——
In Vivo

——
Synonyms

PS423
Pathway

PI3K/Akt/mTOR signaling
Target

PDK
Recptor

PDK
Research Area

——
Indication

——

CAS Number

1221964-37-9
Formula Weight

524.445
Molecular Formula

C25H23F3O9
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(OCOC(C)=O)C(C(C1=CC=CC=C1)CC(C2=CC=C(C(F)(F)F)C=C2)=O)C(OCOC(C)=O)=O
Chemical Name

Bis(acetoxymethyl) 2-[3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]malonate

1. Busschots K, et al. Chem Biol. 2012 Sep 21;19(9):1152-63. 2. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14.

Calculator

molnova catalog