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PS 423
CAS No. 1221964-37-9
PS 423( PS423 )
Catalog No. M10841 CAS No. 1221964-37-9
PS 423 is a substrate-selective inhibitor of PDK1, inhibits the phosphorylation and activation of S6K.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NamePS 423
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NoteResearch use only, not for human use.
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Brief DescriptionPS 423 is a substrate-selective inhibitor of PDK1, inhibits the phosphorylation and activation of S6K.
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DescriptionPS 423 is a substrate-selective inhibitor of PDK1, inhibits the phosphorylation and activation of S6K without affecting the PKB/Akt signaling pathway in HEK293 cells, the prodrug of PS210; inhibits glucose uptake in C2C12 myoblasts; inhibits S6K but not PKB/Akt downstream signaling in muscle cells.
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In Vitro——
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In Vivo——
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SynonymsPS423
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PathwayPI3K/Akt/mTOR signaling
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TargetPDK
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RecptorPDK
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Research Area——
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Indication——
Chemical Information
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CAS Number1221964-37-9
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Formula Weight524.445
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Molecular FormulaC25H23F3O9
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(OCOC(C)=O)C(C(C1=CC=CC=C1)CC(C2=CC=C(C(F)(F)F)C=C2)=O)C(OCOC(C)=O)=O
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Chemical NameBis(acetoxymethyl) 2-[3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]malonate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Busschots K, et al. Chem Biol. 2012 Sep 21;19(9):1152-63.
2. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14.
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