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Home - Products - Neuroscience - GluR - JNJ-46778212

JNJ-46778212

CAS No. 1363281-27-9

JNJ-46778212( —— )

Catalog No. M33390 CAS No. 1363281-27-9

JNJ-46778212 (VU 0409551) is a potent and selective mGlu5 allosteric modulator (EC50: 260 nM) used for neurodissection studies.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 35 In Stock
5MG 32 In Stock
10MG 56 In Stock
25MG 122 In Stock
50MG 203 In Stock
100MG 325 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    JNJ-46778212
  • Note
    Research use only, not for human use.
  • Brief Description
    JNJ-46778212 (VU 0409551) is a potent and selective mGlu5 allosteric modulator (EC50: 260 nM) used for neurodissection studies.
  • Description
    JNJ-46778212 (VU 0409551) is an mGlu5 positive allosteric modulator with an EC50 of 260 nM.
  • In Vitro
    ——
  • In Vivo
    In oral brain/plasma studies, JNJ-46778212 displays excellent CNS penetration. JNJ-46778212 enhances NMDAR function and rescues long-term potentiation in hippocampal slices obtained from SR?/? mice. The administration of JNJ-46778212 to SR?/? mice reverses their deficits in several neuroplasticity signaling pathways and improves their contextual fear memory.
  • Synonyms
    ——
  • Pathway
    Neuroscience
  • Target
    GluR
  • Recptor
    GluR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1363281-27-9
  • Formula Weight
    352.36
  • Molecular Formula
    C20H17FN2O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (283.80 mM; Ultrasonic )
  • SMILES
    Fc1ccc(cc1)C(=O)N1CCc2nc(COc3ccccc3)oc2C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Conde-Ceide S, et al. Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia. ACS Med Chem Lett. 2015 May 20;6(6):716-20.?
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