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Home - Products - Neuroscience - GluR - JNJ-46778212

JNJ-46778212

CAS No. 1363281-27-9

JNJ-46778212( —— )

Catalog No. M33390 CAS No. 1363281-27-9

JNJ-46778212 (VU 0409551) is a potent and selective mGlu5 allosteric modulator (EC50: 260 nM) used for neurodissection studies.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 53 Get Quote
10MG 93 Get Quote
25MG 196 Get Quote
50MG 334 Get Quote
100MG 524 Get Quote
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Biological Information

  • Product Name
    JNJ-46778212
  • Note
    Research use only, not for human use.
  • Brief Description
    JNJ-46778212 (VU 0409551) is a potent and selective mGlu5 allosteric modulator (EC50: 260 nM) used for neurodissection studies.
  • Description
    JNJ-46778212 (VU 0409551) is an mGlu5 positive allosteric modulator with an EC50 of 260 nM.
  • In Vitro
    ——
  • In Vivo
    In oral brain/plasma studies, JNJ-46778212 displays excellent CNS penetration. JNJ-46778212 enhances NMDAR function and rescues long-term potentiation in hippocampal slices obtained from SR?/? mice. The administration of JNJ-46778212 to SR?/? mice reverses their deficits in several neuroplasticity signaling pathways and improves their contextual fear memory.
  • Synonyms
    ——
  • Pathway
    Neuroscience
  • Target
    GluR
  • Recptor
    GluR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1363281-27-9
  • Formula Weight
    352.36
  • Molecular Formula
    C20H17FN2O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (283.80 mM; Ultrasonic )
  • SMILES
    Fc1ccc(cc1)C(=O)N1CCc2nc(COc3ccccc3)oc2C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Conde-Ceide S, et al. Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia. ACS Med Chem Lett. 2015 May 20;6(6):716-20.?
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