Caroverine HCL( —— )

Catalog No. M24545 CAS No. 55750-05-5

Caroverine HCL is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. It is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action, and can be used for the research of inner ear tinnitus.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	41	In Stock
5MG	37	In Stock
10MG	61	In Stock
25MG	126	In Stock
50MG	212	In Stock
100MG	368	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

Caroverine HCL
Note

Research use only, not for human use.
Brief Description

Caroverine HCL is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. It is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action, and can be used for the research of inner ear tinnitus.
Description

Caroverine HCL is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. It is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action, and can be used for the research of inner ear tinnitus.
In Vitro

Caroverine (1 μM; pretreated for 10 min) inhibits the pressor response to KCl (80 mM) andnoradrenaline (1 μM) in the rat hindquarter preparation. Caroverine markedly suppresses the contraction caused by KCl (40 mM) in the rat isolated aorta.
In Vivo

Caroverine (1.44 mg/rat; s.c; 1.0 mL/h for 72 h) attenuates impulse noise-induced hearing loss in the rat. Animal Model:Sprague-Dawley rats of either sex (250-300 g) received impulse noise exposure Dosage:1.44 mg/rat Administration:20 mg/mL; s.c. 1.0 mL/h for 72 h Result:Significantly protected the cochlea against impulse noise trauma.
Synonyms

——
Pathway

Neuroscience
Target

GluR
Recptor

AMPA|NMDA
Research Area

——
Indication

——

Chemical Information

CAS Number

55750-05-5
Formula Weight

401.9
Molecular Formula

C22H28ClN3O2
Purity

>98% (HPLC)
Solubility

DMSO:100 mg/mL (248.80 mM; Need ultrasonic)
SMILES

O=C1N(CCN(CC)CC)C2=C(C=CC=C2)N=C1CC3=CC=C(OC)C=C3.[H]Cl
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Ishida Y, et, al. Vasorelaxant action of caroverine fumarate (a quinoxaline derivative), a calcium-blocking agent. Br J Pharmacol. 1980;71(1):343-8.

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