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Caroverine HCL
CAS No. 55750-05-5
Caroverine HCL( —— )
Catalog No. M24545 CAS No. 55750-05-5
Caroverine HCL is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. It is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action, and can be used for the research of inner ear tinnitus.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 41 | In Stock |
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| 5MG | 37 | In Stock |
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| 10MG | 61 | In Stock |
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| 25MG | 126 | In Stock |
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| 50MG | 212 | In Stock |
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| 100MG | 368 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCaroverine HCL
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NoteResearch use only, not for human use.
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Brief DescriptionCaroverine HCL is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. It is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action, and can be used for the research of inner ear tinnitus.
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DescriptionCaroverine HCL is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. It is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action, and can be used for the research of inner ear tinnitus.
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In VitroCaroverine (1 μM; pretreated for 10 min) inhibits the pressor response to KCl (80 mM) andnoradrenaline (1 μM) in the rat hindquarter preparation. Caroverine markedly suppresses the contraction caused by KCl (40 mM) in the rat isolated aorta.
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In VivoCaroverine (1.44 mg/rat; s.c; 1.0 mL/h for 72 h) attenuates impulse noise-induced hearing loss in the rat. Animal Model:Sprague-Dawley rats of either sex (250-300 g) received impulse noise exposure Dosage:1.44 mg/rat Administration:20 mg/mL; s.c. 1.0 mL/h for 72 h Result:Significantly protected the cochlea against impulse noise trauma.
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Synonyms——
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PathwayNeuroscience
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TargetGluR
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RecptorAMPA|NMDA
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Research Area——
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Indication——
Chemical Information
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CAS Number55750-05-5
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Formula Weight401.9
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Molecular FormulaC22H28ClN3O2
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Purity>98% (HPLC)
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SolubilityDMSO:100 mg/mL (248.80 mM; Need ultrasonic)
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SMILESO=C1N(CCN(CC)CC)C2=C(C=CC=C2)N=C1CC3=CC=C(OC)C=C3.[H]Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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1H-Pyrrolo[2,1-c][1,...
1H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aR)- is a low activity isomer of S 18986.
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VU6012962
VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).
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Basimglurant
Basimglurant is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM). In competition binding experiments on human recombinant mGlu5, Basimglurant (RG7090) fully displaces [3H]-MPEP with a Ki of 35.6 nM and [3H]-ABP688 with a Ki of 1.4 nM. In HEK293 cells stably expressing human mGlu5, Basimglurant (RG7090) inhibits quisqualate induced Ca2+ mobilization with an IC50 of 7.0 nM and [3H]-inositolphosphate accumulation (IC50 of 5.9 nM).
